نتایج جستجو برای: linker
تعداد نتایج: 11693 فیلتر نتایج به سال:
Background and purpose: In recent years, the incidence of cancers has increased in the world. Therefore, many researches have focused on new strategies for treatment of cancers. Previous studies showed that quinolone antibacterials can inhibit human topoisomerases at high concentrations and can be considered as potential cytotoxic agents. On the other hand, 5,7-dibromoisatin is a cytotoxic agen...
Introduction: Among 3 to 30 percent of women of reproductive age, experience abnormal uterine bleeding (AUB). Vaginal rings are one of the systems of interest for the local delivery of hormones that due to their polymeric structure allow prolonged release of drug. In this study, the design and fabrication of matrix vaginal rings containing levonorgestrel (LNG) were investigated. Methods: In th...
We developed a series of highly crystalline double-cable conjugated polymers for application in single-component organic solar cells (SCOSCs). These contain backbones as electron donor and pendant perylene bisimide units (PBIs) acceptor. PBIs are connected to the backbone via alkyl varying from hexyl (C6H12) eicosyl (C20H40) flexible linkers. For with short linkers, tend stack head-to-head fash...
The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally selected based on intuition. Without a reliable selection criterion, the design of such linkers is often difficult, particularly in situations where longer linker sequences are required. Here we describe a program c...
Transforming growth factor-beta (TGF-beta)/Smads regulate a wide variety of biological responses through transcriptional regulation of target genes. Smad3 plays a key role in TGF-beta/Smad-mediated transcriptional responses. Here, we show that the proline-rich linker region of Smad3 contains a transcriptional activation domain. When the linker region is fused to a heterologous DNA-binding domai...
Defining the mechanical and biochemical determinates of kinesin processivity is important for understanding how diverse kinesins are tuned for specific cellular functions. Because transmission of mechanical forces through the 14-18 amino acid neck linker domain underlies coordinated stepping, we investigated the role of neck linker length, charge, and structure in kinesin-1 and kinesin-2 motor ...
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody-drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy was exemplified with a β-glucuronidase-cleavable auristatin E construct. The drug-linker was found to efficiently release free auristatin E (AE) in the presen...
Linker histones are essential for chromatin filament formation, and they play key roles in the regulation of gene expression. Despite the determination of structures of the nucleosome and linker histones, the location of the linker histone on the nucleosome is still a matter of debate. Here we show by computational docking that the globular domain of linker histone variant H5 (GH5) has three di...
The apparent diversity of linker histone subtypes may be related to their specific roles in defining functional states of chromatin in vivo. We have developed a novel method to study constitutive peptides throughout the cell cycle and have demonstrated that an exogenous linker histone could be introduced into a living cell of the slime mold Physarum polycephalum. Here, we have used this method ...
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