1. Intracellular cation composition has been measured in the red cells from twenty patients with hyperthyroidism. The mean concentration of sodium was 11.18 m-mole/l red cells; in sixty normal control subjects the mean red cell sodium level was 7.04 m-mole/l. The difference between these two groups was highly significant. There was no measurable difference between the potassium concentration an...

Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth...

This study was undertaken to investigate the effects of fluoride on growth and thyroid function in young pigs. Three groups of eight crossbred barrows were exposed to 100, 250, and 400 mg F–/kg (from NaF) in their diets for 50 days. Compared to a control group of eight pigs, the average daily gain in weight was significantly reduced, and serum thyroxine (T4) and free thyroxine (FT4) levels also...

The Na,K-ATPase alpha isoform (alpha 1, alpha 2, and alpha 3) and beta subunit genes exhibit a complex pattern of expression during heart development. To identify possible molecular signals that regulate the differential expression of these genes, isolated neonatal rat myocardial and non-myocardial cells were cultured in chemically defined medium and the responses of the multiple Na,K-ATPase su...

Addition of sodium salicylate to human serum at concentrations often obtained during aspirin therapy causes 100-200% increases in free triiodothyronine (T(3)) and free thyroxine (T(4)) as estimated by ultrafiltration. The increase in free T(3) was unexpected since previous data had suggested that salicylate inhibits binding of T(4) only to thyroxine-binding prealbumin (TBPA) and that T(3) is no...

The influences of hypothyroidism on behavioral measures of the taste function in male and female Long-Evans rats were determined. Experimental rats' preferences for and ability to detect NaCl, HCl, sucrose, and quinine sulfate were examined before, during, and after 9 weeks of maintenance on 0.1% propylthiouracil (PTU), an agent that produces marked hypothyroidism, with similar determinations m...