BACKGROUND Age at onset of Huntington's disease (HD) is largely determined by the CAG trinucleotide repeat length in the HTT gene. Importantly, the CAG repeat undergoes tissue-specific somatic instability, prevalent in brain regions that are disease targets, suggesting a potential role for somatic CAG repeat instability in modifying HD pathogenesis. Thus, understanding underlying mechanisms of ...

Aflatoxin B1 (AFB1) is a potent carcinogen that causes growth stunting, immunosuppression and liver cancer in multiple species. The recent trend of replacing fishmeal with plant-based proteins in fish feed has amplified the AFB1 exposure risk in farm-raised fish. NovaSil (NS), a calcium montmorillonite clay, has previously been shown to reduce AFB1 bioavailability safely and efficaciously in se...

Polycystic liver disease (PCLD) is an autosomal dominant disorder characterised by multiple fluid filled cysts in the liver. This rare disease is caused by heterozygous germline mutations in PRKCSH and SEC63. We previously found that, in patients with a PRKCSH mutation, over 76% of the cysts acquired a somatic 'second-hit' mutation in the wild type PRKCSH allele. We hypothesise that somatic sec...

Objective: Somatic symptom disorder (SSD) is characterized by somatic symptoms that are very distressing or cause considerable functional disability. SSD is associated with various medical and psychiatric conditions and imposes high costs on the patient's health care system. Therefore, diagnosis and treatment of SSD are crucial. The Somatic Symptom Scale-8 (SSS-8) is a valuable and brief self-r...

in the present study, some biological aspects of capoeta trutta (heckel, 1843) have been examined for the aim of future stock assessment, exploitation and conservational managements. a total of 103 fish specimens were collected seasonally from seymareh river, tigris basin, iran, in four seasons during 2011-2012. observed maximum age was 4 + in both sexes and sex ratio obtained as 1m:1.9f. analy...

OBJECTIVE The Somatosensory Amplification Scale (SSAS) purports to measure the extent to which individuals are sensitive to their bodies. The present study examined the psychometric properties of the SSAS in two studies with university students. METHODS Participants completed the SSAS, various cross-sectional measures of somatic and psychological distress, longitudinal measures of somatic sym...

Protein ingredients for formulation of fish feeds are expensive and have limited availability. Therefore, reducing dietary protein while increasing fat content is a common practice in rearing carnivorous species. However, the ability L-carnitine to alleviate adverse effects such diets currently unknown. This study investigated role supplementation alleviating on growth performance, energy metab...

The last remaining population of European sturgeon (Acipenser sturio) lives in the Gironde-Garonne-Dordogne (France) catchment (GGD). Captive young individuals are released into GGD hydrosystem each year, as part a restocking programme. This study aims to assess health status juveniles A. sturio current conditions hydrosystem, evaluate their capacity survive and grow moderately anthropized ecos...