Motivation Loss-of-function genetic variants are frequently associated with severe clinical phenotypes, yet many are present in the genomes of healthy individuals. The available methods to assess the impact of these variants rely primarily upon evolutionary conservation with little to no consideration of the structural and functional implications for the protein. They further do not provide inf...

background outer hair cells' (ohcs') dysfunctions as the extent of temporary and permanent threshold shifts (tts and pts) and cochlear damage were assessed in rabbits exposed to continuous noise methods twelve new zealand white rabbits were studied in noise (n) (n=6; exposed to continuous noise; 95 db spl, 500-8000 hz for 8 h per day during 5 consecutive days) and control (c) (n=6; no...

Shrinkage preliminary test estimation in exponential distribution under a precautionary loss function is considered. The minimum risk-unbiased estimator is derived and some shrinkage preliminary test estimators are proposed. We apply our results on censored data and records. The relative efficiencies of proposed estimators with respect to the minimum ‎risk-unbiased‎&...

the problem of estimating the parameter ?, when it is restricted to an interval of the form , in a class of discrete distributions, including binomial negative binomial discrete weibull and etc., is considered. we give necessary and sufficient conditions for which the bayes estimator of with respect to a two points boundary supported prior is minimax under squared log error loss function. for s...

Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, affecting 7% of this population. Although not entirely understood, the etiology of PCOS is closely linked to obesity and abdominal adiposity that are considered to worsen the clinical presentation, particularly menstrual irregularities and hyperandrogenism. Lifestyle mo...

the improved estimator of the variance in the general linear model is presented under an asymmetric linex loss function.

in a subclass of the scale-parameter exponential family, we consider the sequential pointestimation of a function of the scale parameter under the loss function given as the sum of the weightedsquared error loss and a linear cost. for a fully sequential sampling scheme, second order expansions areobtained for the expected sample size as well as for the regret of the procedure. the former resear...