The use of low molecular weight heparins (LMWH) in obstetric care has grown considerably since their introduction into clinical practice in the early 1990s. However, because of the physiological changes of pregnancy, the predictable pharmacokinetic profile of LMWH is lost and some uncertainty exists around the optimal dosing regimen for LMWH in obstetric care. Two recent United Kingdom prospect...

The structural and photoluminescence (PL) properties of thin films of poly(3-hexylthophene) (P3HT) with molecular weights (MWs) of 3000 and 13,300 have been investigated. Although high MW P3HT always self-organizes into one packing structure (form I), low MW P3HT forms two different packing structures (forms I and II) depending on the fabrication conditions. In this work, several fabrication te...

Porcine intestinal mucosal heparin induced aggregation of platelets in citrated platelet-rich plasma and enhanced platelet aggregation and serotonin secretion induced by other agents. This action of heparin was blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase. The effect was not inhibited by apyrase or by N-amylthio-5'-AMP and t...

BACKGROUND Low-molecular-weight heparins are effective for treating venous thrombosis, but their cost-effectiveness has not been rigorously assessed. OBJECTIVE To evaluate the cost-effectiveness of low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis. DESIGN Decision model. DATA SOURCES Probabilities for clinical outcomes were ob...

not received.