The MAL (MAL/VIP17) proteolipid is a nonglycosylated integral membrane protein expressed in a restricted pattern of cell types, including T lymphocytes, myelin-forming cells, and polarized epithelial cells. Transport of the influenza virus hemagglutinin (HA) to the apical surface of epithelial Madin-Darby canine kidney (MDCK) cells appears to be mediated by a pathway involving glycolipid- and c...

Résumé. Nous décrivons un processus de fouille de données en bioinformatique. Il se traduit par la spécification de modèles de Markov cachés du second-ordre, leur apprentissage et leur utilisation pour permettre une segmentation de grandes séquences d’ADN en différentes classes qui traduisent chacune un état organisationnel et structural des motifs d’ADN locaux sous-jacents. Nous ne supposons a...

Hypothesis Anthocyanins possess well-known biological effects and suppress DNA damage induced by therapeutic topoisomerase poisons. Our study focusses on the modulatory effects of anthocyanidins-malvidin (MAL) and pelargonidin (PEL)-on topoisomerase II poison mitoxantrone (MXT)-induced cytotoxicity and genotoxicity in in vitro and in vivo conditions. Study design HepG2 cells were treated with M...

Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamm...

This paper builds on altruistic locking which is an extension of 2PL. It allows more relaxed rules as compared to 2PL. But altruistic locking too enforces some rules which disallow some valid schedules (present in VSR and CSR) to be passed by AL. This paper proposes a multiversion variant of AL which solves this problem. The report also discusses the relationship or comparison between different...

The Materialized Aggregate List (MAL) enables effective storing and processing of long aggregates lists. The MAL structure contains an iterator table divided into pages that stores adequate number of aggregates. Time complexity of three algorithms was calculated and, in comparison with experimental results, the best configuration of MAL parameters (number of pages, single page size and number o...

The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yet identified a function for Mal distinct from the related adapter MyD88. In this study, we have identified a putative TRAF6 interaction site in Mal but not in MyD88 and we demonstrate that Mal can be co-immu...

The renal-specific Na+-K+-2Cl- cotransporter (NKCC2) is the major salt transport pathway of the apical membrane of the mammalian thick ascending limb of Henle's loop. Here, we analyze the role of the tetraspan protein myelin and lymphocytes-associated protein (MAL)/VIP17 in the regulation of NKCC2. We demonstrated that 1) NKCC2 and MAL/VIP17 colocalize and coimmunoprecipitate in Lilly Laborator...

Background: Malathion (MAL) is a choice insecticide in the stored grain in different countries. The aim of the present study is to evaluate toxicological effects of 30-day intake of MAL on the male reproductive system of Wistar rats. Methods: This research was ethically approved by the local authority at Faculty of Medicine, Monastir, Tunisia. Three MAL treated groups received 1 ml...

JCB • VOLUME 178 • NUMBER 2 • 2007 182 Actin, the great orchestrator C hanges in cell shape or mobility require changes in gene expression. In a new study, Maria Vartiainen, Sebastian Guettler, Banafshe Larijani, and Richard Treisman (Cancer Research UK, London, UK) reveal how actin coordinates both shape and transcription at once. Actin rapidly polymerizes into a fi lamentous (F) form in respo...