In this paper, we describe systematic analogical reasoning using a qualitative spatial model for manufactured components which incorporates both features and mathematical spatial relationships between features [7]. Solving this problem will be of benefit to manufacturing planning. We will discuss the definition and formulation of these computations] inferencing tasks, as well as their propertie...

Abstract Levetiracetam as an Anti-epileptic drug with exclusive mechanism of action is accepted by the USA Food and Drug Administration as an adjunctive therapy in treating epilepsy in young adults. The purpose of this project is the design and formulation of prolonged release of levetiracetam using two types of retarding agent such as Hydroxyl Propyl Methylcellulose (HPMC K4...

The current competitive environment is characterized by new sources of information, new technologies, new management practices, new competitors, and shorter product life cycles, which highlights the importance of organizational knowledge in manufacturing companies. We integrate some of those knowledge-based approaches seeking to understand how aspects related to cross-functional orientation, ne...

Premix formulation has a dramatic impact on premix handling and feed distribution characteristics, potential drug loss during the feed manufacturing and delivery process, and drug stability under adverse conditions such as pelleting or harsh environmental temperatures. Ultimately, premix formulation has a direct effect on the amount of drug presented to the pig’s digestive tract for disease tre...

BACKGROUND Orodispersible tablets (ODTs) are tablet or wafer forms of medication that disintegrate in the mouth, aided only by saliva. ODTs rely on different fast dissolve/disintegration manufacturing technologies. OBJECTIVES Disintegration time differences for several olanzapine ODT forms were investigated. Risperdal M-Tab(®) was included as a non-olanzapine ODT comparator. RESEARCH DESIGN...

Parallel-batch machine problems arise in numerous manufacturing settings from semiconductor manufacturing to printing. They have recently been addressed in constraint programming (CP) via the combination of the novel sequenceEDD global constraint with the existing pack constraint to form the current state-of-the-art approach. In this paper, we present a detailed analysis of the problem and deri...

Most of the research on aggregate production planning has been focused on discrete parts manufacturing models. In environments where intermediate inventory cannot be stored, and multiple products are produced simultaneously using complex con$gurations of production machines, these models may produce erroneous results. In this paper, we present a con$guration-based formulation for one such manuf...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...