Hopping provides efficient and energy saving locomotion for kangaroos, but it results in great forces in the knee joints. A previous study has suggested that a unique fibrous cartilage in the central region of the tibial cartilage could serve to decrease the peak stresses generated within kangaroo tibiofemoral joints. However, the influences of the microstructure, composition and mechanical pro...

The central hypothesis of functional tissue engineering is that an engineered construct can serve as a viable replacement tissue in vivo by replicating the structure and function of native tissue. In the case of articular cartilage, this requires the reproduction of the bulk mechanical and surface lubrication properties of native hyaline cartilage. Cartilage tissue engineering has primarily foc...

Background: Recent studies have provided evidence that integrins play roles in recognition of mechanical stimuli and its translation into a cellular response. Integrin signaling may be regulated by a number of mechanisms including accessory proteins such as CD98 (4F2 antigen). Objectives: To determine CD98 expression by human articular chondrocytes and its involvement in human articular mechano...

INTRODUCTION There have been many attempts to repair full-thickness articular cartilage defects using tissue-engineering techniques, focusing particularly on the regeneration of high-strength cartilage. Unfortunately, the strength is insufficient for fixation of the grafted part on large defect of joint surface. Current focus in our laboratory has been placed on the development of a novel silk ...

collagen is the major protein component of cartilage, bone, skin and connective tissue and constitutes the major part of the extracellular matrix. collagen type i has complex structural hierarchy, which consists of treepolypeptide α-chains wound together in a rod-like helical structure. collagen is an important biomaterial, finding many applications in the field of tissue engineering. it has be...

Cartilage tissue engineering strategies generally result in homogeneous tissue structures with little resemblance to the native zonal organization of articular cartilage. The objective of this study was to use bilayered photopolymerized hydrogels to organize zone-specific chondrocytes in a stratified framework and study the effects of this three-dimensional coculture system on the properties of...

Poly(3-hydroxybutyrate) (PHB)/chitosan electrospun scaffold was recently prepared for cartilage tissue engineering purpose. The drawback of this scaffold was its low mechanical properties. This study was carried out to see if addition of multi-wall carbon nanotubes (MWNTs) to PHB/chitosan polymeric blend can show better mechanical and structural properties. To do this, three different amounts o...

The purpose of this study was to determine suture-holding properties of tissue-engineered neocartilage relative to native articular cartilage. To this end, suture pull-out strength was quantified for native articular cartilage and for neocartilages possessing various mechanical properties. Suture-holding properties were examined in vitro and in vivo. Neocartilage from bovine chondrocytes was en...

background : in recent years tissue engineering developed to replace or repair damaged tissues using cell and biomaterial. one of the most important fields of tissue engineering is simulation of in vivo micro environment of body tissues. this study aimed to develop culture chamber and cell biomaterial sheet engineering for the reconstruction of cartilage tissue. methods : stainless steel cultur...