We report two cases of primary cold agglutinin disease (CAD) associated with megaloblastic anemia in Japanese elderly patients. Case 1 was a 67-year-old male and Case 2 was a 55-year-old male. Both patients were diagnosed with primary CAD, with continuously high cold agglutinin titers (1 : >8,192 and 1 : 16,834, resp.), monoclonal IgM-kappa light chains, and no underlying disease. In addition, ...

The erythrocyte membrane protein pattern of patients with megaloblastic anemia was determined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. In severe megaloblastic anemia, secondary either to folic acid or vitamin B12 deficiency, the erythrocyte membrane protein pattern was grossly abnormal, lacking bands 1, 2 (spectrin), and 3 and having several diffuse, faster migrating ban...

N ASSOCIATION BETWEEN megaloblastic anemia and therapy for tuberculosis has been described previously in five instances.1-3 In three patients megaloblastic erythropoiesis was associated with sideroblastic changes in the bone marrow,1’2 and in two the megaloblastic anemia was attributed .o deficiency of vitamin B12 resulting from malabsorption of this vitamin induced by therapy with para-amirios...

By Fru rn mci A. Kur’sitm t m JoHN Li Er AUM S INCE THE INITIAL case reports in 1949,1,2 the occurrence of megaloblastic anemia as a complication of alcoholic cirrhosis has been reported with increasing frequency in recent years.314 Jarrold and Vilter reviewed the marrows of 30 patients with cirrhosis and found 3 to be megaloblastic.1 Krasnow et al. found the incidence of megaloblastic anemia i...

The content of folate activity precursors in washed red cells and the enzymatic plasma factor activity, necessary for the release of folate from the precursors, were studied in normal subjects and in patients with megaloblastic anaemia of pregnancy. Subjects with megaloblastic anaemia of pregnancy had a significantly reduced folate activity precursor content, and 14 subjects (58%) had significa...

Deficiency of folate or vitamin B12 (cobalamin) causes megaloblastic anemia, a disease characterized by pancytopenia due to the excessive apoptosis of hematopoietic progenitor cells. Clinical and experimental studies of megaloblastic anemia have demonstrated an impairment of DNA synthesis and repair in hematopoietic cells that is manifested by an increased percentage of cells in the DNA synthes...

By Fru rn mci A. Kur’sitm t m JoHN Li Er AUM S INCE THE INITIAL case reports in 1949,1,2 the occurrence of megaloblastic anemia as a complication of alcoholic cirrhosis has been reported with increasing frequency in recent years.314 Jarrold and Vilter reviewed the marrows of 30 patients with cirrhosis and found 3 to be megaloblastic.1 Krasnow et al. found the incidence of megaloblastic anemia i...

There is a significant fall in the serum folic acid level during pregnancy, reaching its lowest level at term. This is most pronounced in twin pregnancies. A similar but less spectacular fall occurs in the vitamin B(12) concentration. In megaloblastic anaemia both folic acid and vitamin B(12) levels are lower than in other pregnant women. The degree of megaloblastic change in the bone marrow, a...