A bi-directional many-sided explanation typed multi-step validation method including its implementation architecture has been proposed to diminish validation loads for busy experts. This paper presents a validation tool based on this method. This tool supports the multi-step, bi-directional validation by experts, KEs (Knowledge Engineers) and computers on the Intra/lnternet environment. Particu...

The color developing reaction between ambrisentan and 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ) or 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CLA) was successfully employed in the development of two simple and sensitive spectrophotometric methods (M1 and M2) for the determination of ambrisentan in its pharmaceutical dosage forms.The methods are based on the charge transfer reaction of ...

Alpha-hydroxylic acids are widely used in the treatment and control of skin disorders. Azelaic acid is a naturally occuring Alpha-hydroxy acid that can be formed endogenously from long-chain dicardoxylic acids, metabolism of oleic acid or omega oxidation of mono carboxylic acids. It shows bacteriostatic and bactericidal activities against aerobic and anaerobic micro-organisms present on acne-be...

To diminish the validation load on busy experts, a bi-directional, many-sided explanation typed multi-step validation method (MMBV) was proposed, which can decrease the validation tasks of experts (Tsuruta et al., 2000). This paper proposes the extension of MMBV. In this method, through the validation results and comments of experts, validation knowledge can be automatically acquired as case-ba...

The objective of the study was to develop a simple, specific and stability-indicating HPLC method for the simultaneous determination of creatine phosphate sodium (CPS) and its related substances in pharmaceutical formulation. Separation of creatine phosphate sodium from its major process impurities and degradation products was achieved on a Hypersil BDS C18 column (250 × 4.6 mm, 5 μm) with an a...

This paper presents an empirical study on the visual method for cluster validation based on the Fastmap projection. The visual cluster validation method attempts to tackle two clustering problems in data mining: ( I ) to veri f y partitions of data created by a clustering algorithm and ( 2 ) to identify genuine clusters from data partitions. They are achieved through projecting objects and clus...

investigating nozzle’s orifice flow is challenging both experimentally and theoretically. this paper focuses on simulating flow inside diesel injector nozzle via ansys fluent v15. validation is performed with experimental results from winkhofler et al (2001). several important parameters such as mass flow rate, velocity profiles and pressure profiles are used for this validation. results includ...

The objective of the study was to develop a simple, specific and stability-indicating HPLC method for the simultaneous determination of creatine phosphate sodium (CPS) and its related substances in pharmaceutical formulation. Separation of creatine phosphate sodium from its major process impurities and degradation products was achieved on a Hypersil BDS C18 column (250 × 4.6 mm, 5 μm) with an a...