the objective of the study was to develop a simple, specific and stability-indicating hplc method for the simultaneous determination of creatine phosphate sodium (cps) and its related substances in pharmaceutical formulation. separation of creatine phosphate sodium from its major process impurities and degradation products was achieved on a hypersil bds c18 column (250 × 4.6 mm, 5 μm) with an a...

just like any other process, vaccine manufacturing procedures are defined as a series of interrelated functions and activities using a variety of specified actions and equipment designed to produce a defined product. to assure the reproducibility and consistency of such processes, they must be carried out using validated equipment and under the established procedures that meet all the acceptanc...

the present work describes a reverse phase hplc method for the quantitation of drotaverine hydrochloride and mefenamic acid in human plasma. organic solvent system used for liquid extraction composed of dichloromethane, and isopropyl alcohol in the ratio 80:20 (v/v). the compounds were separated on a thermo bds hypersil c8 (25.0 cm×4.6 mm, 5 µm particle size) column in isocratic mode with a mix...

objective(s): reliability measures precision or the extent to which test results can be replicated. this is the first ever systematic review to identify statistical methods used to measure reliability of equipment measuring continuous variables. this studyalso aims to highlight the inappropriate statistical method used in the reliability analysis and its implication in the medical practice.   m...

since the change of land use accrued in the iran, especially in northern iran, this research aims tocompare the spatial variability of soil properties in three adjacent land uses including cultivated by wheat lands, grazing lands and forest lands covered by juniperus sp,  fagus orientalis, quercus castanifolia, and acer velotinum species in kiasar region, mazandaran province, northern iran. som...

gabapentin is an anticonvulsant widely used in the treatment of epilepsy.an accurate and validated spectrophotometric method was developed as an alternative method to determine gabapentin in pharmaceutical products. this is a simple, accurate, precise, selective and visible spectrophotometric method. the method is based on the measurement of drug absorbance as a result of yellow solution format...

objective: different categories are available for estimating of radiation dose. radioisotopes with the same energy and almost the same physical properties have similar effects. monte carlo technique is a computerized method based on mathematical simulation of physical processes. the main purpose of this study is to show that beta particles are not able to penetrate deep into the water. also dif...

In pharmaceutical industries, the validation of analytical methods is used to demonstrate that the method is fitted for its purpose; it must follow a plan which includes scope, performance characteristics, and acceptance limits. Analytical methods need to be validated or revalidated prior to their introduction into routine analyses (release of batch). The overarching philosophy in current good ...