Objective(s):miR-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (GCT) of bone remains poorly understood. The current study aimed to investigate the potential role and mechanism of miR-125b in GCT. Materials and Methods:Expression levels of miR-125b in GCT tissues were determined using RT-PCR. The cell proliferation was surveyed by direct cell coun...

objective: cardiac cell differentiation with the help of mirnas has recently opened a promising window for the restoration of myocardial infarction. independent mir-1-2/133a-1 and mir-206/133b clusters are known to be expressed in cardiac and skeletal muscles, respectively. mir-133b differs from mir-133a by only one nucleotide. the sequence similarity of these two mirnas suggests that they targ...

One of the mechanisms for development autoimmune diseases is changes in epigenetic regulation, root causes which have not yet been established. At same time, data on role transposons as sources long noncoding ribonucleic acids (RNA) and microRNAs involved immune pathology accumulated. In evolution, transposable elements become basis emergence V(D)J recombination regulation HLA genes. Pathologic...

Epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. Mesial Temporal Lobe Epilepsy (MTLE) is the most common type of refractory epilepsy. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of MTLE. Hundreds of micro-RNAs have been found to be abnormally expressed in epilept...

Purpose: To investigate the effects of miR-34a and miR-26b on targeted genes, LEF1 EphA2, proliferation apoptosis OPCN-1.Methods: Sixty specimens cancer tissue (CT) equivalent adjacent to tumors (TAT) were collected from prostate patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used determine mRNA expression levels miR-34a, miR-26b, LEF1, EphA2 in above tissu...