mitochondrial permeability transition pore

marzieh amirmostofian department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, ir iran. jalal pourahmad jaktaji department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences, tehran, ir iran. zohreh soleimani department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, ir iran. kimia tabib department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, ir iran. farahnaz tanbakosazan department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences, tehran, ir iran. mirdavood omrani department of genetics, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran.

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

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Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

Journal: The Iranian Journal of Pharmaceutical Research 2013

Abbasali Motallebi, Jafar Shahraki, Jalal Pourahmad, Marjan Aghvami,

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

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Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

2013

Jason Karch Jennifer Q Kwong Adam R Burr Michelle A Sargent John W Elrod Pablo M Peixoto Sonia Martinez-Caballero Hanna Osinska Emily H-Y Cheng Jeffrey Robbins Kathleen W Kinnally Jeffery D Molkentin

A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondrial pore-dependent necrotic cell death by facilita...

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