Montelukast sodium (Singulair, Merck) is a selective and orally-active leukotriene-receptor antagonist (LTRA) that inhibits the cysteinyl leukotriene 1 (CysLT1) receptor. Montelukast is an effective and well-tolerated preventative treatment for asthma and allergic rhinitis in adults and children. The upper and lower airway show similar inflammatory responses to allergen challenge. Leukotrienes ...

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was induced by administrating 4% dextran sulphate sodium (DSS, MW 45,000) in drinking water for 9 days. Montelukast (10 mg/kg/day) or vehicle was given by gastric...

This study was designed to investigate the clinical effect of montelukast sodium combined with inhaled corticosteroids in the treatment of children with obstructive sleep apnea syndrome (OSAS).One hundred ninety-five children were enrolled and divided into 3 groups: groups A, B, and C; the group A (oral use of montelukast sodium), group B (nasal spray of mometasone furoate), and group C (oral u...

although current guidelines place single leukotriene receptor antagonists use as a therapeutic option in mild persistent asthma, there is still uncertainty about its place. in this study efficiency of montelukast monotherapy in children with moderate persistent asthma was evaluated. children (age 6 to 16) with persistent moderate asthma were treated prospectively with budesonide combined with m...

Objective: Asthma consensus guidelines recommend the use of a controller agent to control asthma symptoms and reduce inflammation in patients with mild asthma. The objective of this study was to compare montelukast to inhaled fluticasone on the percentage of asthma-free days in patients with mild persistent asthma during 48 weeks of active treatment. Methods: This was a randomized, multicenter ...

Montelukast sodium is well known pharmaceutically for its action as leukotriene antagonist and reliving symptoms associated with asthma available in the market tablet, chewable powder. The aim of this study was to develop newly simple selective ultraviolet spectrophotometry (UV) method daily routine analysis quality control department. UV developed wavelength at 287.0 nm. This effectively appli...