Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question. We review the pharmacokinetics/pharmacodynamics of vancomycin metabolism. Efficacy and sa...

In our earlier studies on CCl4 induced acute toxicity model (CCl4 3ml/kg body wt). Abhrak bhasma protects fatty degeneration of liver and associated nephrotoxicity in male albino rats. It had shown to function through production management free radicals (Teli Kanase, 2020a, b). To study further the paths Bhasma mediated protection hepatotoxicity nephrotoxicity, liver, kidney serum lipid content...

Introduction: Drug-induced adverse effects are the major challenging issue in clinical setting of chemotherapy. Kidneys responsible for elimination many chemotherapeutic agents which makes them a common target effects. Nephrotoxicity is deleterious effect carrying great negative impact on body homeostasis and maintenance cellular functions.Aim: The present review aims to focus anticancer-induce...

To date, no comparative clinical studies have investigated the effects of different vancomycin products on nephrotoxicity. The objective of this single-center, retrospective, matched-cohort study was to investigate the impact of two different vancomycin products on the development of nephrotoxicity. The study population included adults receiving a single vancomycin product, from either Pfizer o...

BACKGROUND Amphotericin B is a widely used broad-spectrum antifungal agent, despite being associated with significant adverse events, including nephrotoxicity. METHODS The present prospective study collected data on outcomes for 418 adult patients treated consecutively with polyenes in hematology and oncology wards in 20 hospitals in Europe. RESULTS Patients initially received amphotericin ...

CONTEXT Limited Indian data are available on the rate of colistin nephrotoxicity and other risk factors contributing to the development of this important side effect. AIM This study aims to generate data on colistin nephrotoxicity from a large cohort of Indian patients. DESIGN Retrospective cohort study. MATERIALS AND METHODS Case record analysis of patients who received colistin, in an o...

BACKGROUND Nephrotoxicity is the most clinically significant adverse reaction of amphotericin B. Different aspects of amphotericin B (AmB) nephrotoxicity have not been studied well in our population. OBJECTIVES The purpose of this study was to assess the frequency, time onset, and possible associated factors of AmB nephrotoxicity in hospitalized patients in hematology-oncology wards in the so...

BACKGROUND The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations. We conducted a prospective study to compare their trend of nephrotoxicity in our patient population. METHODS Our study included adult ICU patients wh...

background: nephrotoxicity is one of the major side-effects of cisplatin that has been seen in about 20% of treated patients. the aim of this study was to assess the effectiveness of a forced hydration protocol comprised of isotonic saline, potassium chloride (kcl) and magnesium sulfate (mgso4) on prevention of cisplatin nephrotoxicity. methods: this cross sectional prospective study was perfor...

The pathogenesis of colistin induced nephrotoxicity is poorly understood. Currently there are no effective therapeutic or prophylactic agents available. This study was aimed to determine the mechanism of colistin induced nephrotoxicity and to determine whether P-glycoprotein (P-gp) induction could prevent colistin induced nephrotoxicity. Colistin induced cell toxicity in cultured human proximal...