نتایج جستجو برای: nephrotoxicity

تعداد نتایج: 5501  

Journal: :iranian red crescent medical journal 0
iman karimzadeh department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, shiraz, ir iran; department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, shiraz, ir iran. tel: +98-7132424128 ghazaleh haghighati department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, shiraz, ir iran mani ramzi department of internal medicine, hematology research center, shiraz university of medical sciences, shiraz, ir iran mohammad mahdi sagheb department of internal medicine, nephrology-urology research center, shiraz university of medical sciences, shiraz, ir iran kamiar zomorodian department of medical mycology and parasitology, basic sciences in infectious diseases research center, shiraz university of medical sciences, shiraz, ir iran

conclusions vancomycin nephrotoxicity is common but usually reversible and has readily manageable adverse effect. urine kim-1 was not more accurate than serum or urine creatinine in detecting vancomycin nephrotoxicity in our study population. results thirteen out of the 52 recruited patients (25%) developed nephrotoxicity, with a mean ± standard deviation onset of 11.46 ± 7.56 days. furosemide ...

Journal: :International journal of basic and clinical pharmacology 2023

One of the common causes acute kidney injury (AKI) is drug nephrotoxicity. AKIs around 20-60% in hospitalised patients are caused by drug-induced nephrotoxicity, which also linked to higher morbidity and death both children adults. Antibiotics one most frequently prescribed classes worldwide and, leading contributors Nephrotoxicity has been related a wide range antimicrobial medications, althou...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002
Kayser Caglar Can Kinalp Fikret Arpaci Mustafa Turan Kenan Saglam Bekir Ozturk Seref Komurcu Izzet Yavuz Müjdat Yenicesu Ahmet Ozet Abdülgaffar Vural

BACKGROUND Nephrotoxicity is one of the most frequent dose-limiting factors of high-dose chemotherapy to create tolerance of autologous peripheral blood stem-cell transplantation (PBSCT) for the treatment of malignant diseases. The relative importance of factors that may be responsible for the development of nephrotoxicity varied in different trials. METHODS The factors affecting nephrotoxici...

Journal: : 2022

Background: Nephrotoxicity is referred to as rapid degeneration in kidney functioning due the toxic effects of medications. The glomerulus and proximal renal tubule are fundamental portions nephron be affected by drugs leading nephrotoxicity. Prescribed medications like antibiotics (aminoglycoside, vancomycin), amphotericin B, antidepressants (amitriptyline, fluoxetine), acyclovir, angiotensin-...

2012
Sun Young Kim Aree Moon

Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly due to the damage or destruction of kidney function by exogenous or endogenous toxicants. Exposure to drugs often results in toxicity in kidney which represents the major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. Understanding the toxic mechanisms ...

Journal: :Annals of internal medicine 1983
W M Bennett J P Pulliam

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature anal...

Journal: :The Canadian journal of hospital pharmacy 2014
Claire Contreiras Michael Legal Tim T Y Lau Rosanne Thalakada Stephen Shalansky Mary H H Ensom

BACKGROUND In the past, impurities in vancomycin formulations were thought to contribute to nephrotoxicity. In contrast, when current, purer formulations are dosed at conventional trough levels (i.e., 5-15 mg/L), the incidence of nephrotoxicity is relatively low. Recent guidelines have recommended targeting higher vancomycin trough levels in treatment of complicated methicillin-resistant Staphy...

Background: Cisplatin is an antineoplastic agent used to treat many malignancies; however, the main side effect of cisplatin is nephrotoxicity. The aim of this study was to evaluate the effect of hydration therapy with and without magnesium on prevention of cisplatin-induced nephrotoxicity. Methods: This retrospective study was performed on 46 patients with malignancy who were candidate to rec...

Journal: :nephro-urology monthly 0
iman karimzadeh department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, shiraz, ir iran marziyeh heydari department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, shiraz, ir iran mani ramzi hematology research center, department of internal medicine, shiraz university of medical sciences, shiraz, ir iran mohammad mahdi sagheb nephrology-urology research center, department of internal medicine, shiraz university of medical sciences, shiraz, ir iran; nephrology-urology research center, department of internal medicine, shiraz university of medical sciences, shiraz, ir iran. tel: +98-7132351087

conclusions nearly one-third (27.5%) of our cohort developed nephrotoxicity within the first week of amb treatment. hypokalemia and renal potassium wasting were more notable, affecting about one-half and one-third of the amb recipients, respectively. results among the 40 patients recruited for the study, 11 (27.5%) patients developed amb nephrotoxicity with a mean ± standard deviation onset of ...

2016
Jantien Hoek Karen M. Bloemendal Lilly-Ann A. van der Velden Judi N.A. van Diessen Erik van Werkhoven Willem M.C. Klop Margot E.T. Tesselaar

PURPOSE Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15-29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as creatinine clearance 59-30 mL/min) mentioned. In this study, we asse...

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