The effect of a non-symmetric waveform on nerve conduction block induced by high-frequency biphasic stimulation is investigated using a lumped circuit model of the unmyelinated axon based on Hodgkin-Huxley equations. The simulation results reveal that the block threshold monotonically increases with the stimulation frequency for the symmetric stimulation waveform. However, a nonmonotonic relati...

Nerve conduction studies (NCS) are necessary to distinguish multifocal motor neuropathy (MMN) from other disorders with a similar clinical picture. In MMN, NCS may show a unique combination of conduction block (CB) or conduction slowing consistent with demyelination, whereas sensory conduction in the same nerve is normal. This contribution discusses a relatively simple and practical electrophys...

Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low...

determination of f-wave latency is a simple and valuable method in evaluating proximal part of peripheral nerves. the aim of this study was to determine the mean minimal peroneal f wave (f min) in healthy individuals. a total of 282 individuals were studied. the mean age was 45.6 years. the f min (± sd) for 564 peroneal nerves was 47.09 ± 4.51 ms. the f min for the age group of 20-45 and height...

Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant. The histological studies showed demyelination in the lumbar, sacral and coccygeal dorsal and ventral spinal roots and to a lesser extent in the spinal cord, including the dorsa...

Conduction in rat peripheral nerve has been monitored following the stimulated release of nitric oxide (NO) from diethylamine-NONOate (DEA-NONOate). Branches of the sciatic nerve were dissected, but left otherwise intact, and propagating signals recorded externally. At levels consistent with inflammation, NO exposure resulted in a complete loss of the compound action potential. Conduction was f...