BACKGROUND Extensive facial nerve defects between the facial nerve trunk and its branches can be clinically reconstructed by incorporating double innervation into an end-to-side loop graft technique. This study developed a new animal model to evaluate the technique's ability to promote nerve regeneration. METHODS Rats were divided into the intact, nonsupercharge, and supercharge groups. Artif...

PURPOSE: Two-stage facial reanimation procedures with a cross-facial nerve graft often yield less predictable results in older patients due to multifactorial reasons. Some studies strongly suggest that increased donor nerve axonal load improves function of a free muscle transfer after a crossfacial nerve graft. However, strong studies characterizing the relationship between age and facial nerve...

Nerve regeneration in a sensory nerve was obtained by the application of different techniques: inside-out vein graft (IOVG group) and standard vein graft (SVG group). These techniques provide a good microenvironment for axon regeneration in motor nerves, but their efficiency for regeneration of sensory nerves is controversial. The saphenous nervtce was sectioned and repaired by the inside-out a...

PURPOSE: Two-stage facial reanimation procedures with a cross-facial nerve graft often yield less predictable results in older patients due to multifactorial reasons. Some studies strongly suggest that increased donor nerve axonal load improves function of a free muscle transfer after a crossfacial nerve graft. However, strong studies characterizing the relationship between age and facial nerve...

Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding s...

Background: Peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. Objectives: The purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (ESM) guidance channel with autograft. Materials and Methods: Thirty adult male rats were divided into th...

Objective(s):  The aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (ESM) tube conduit in comparison with autograft. Materials and Methods: Thirty adult male rats (250-300 g) were randomized into (1) ESM conduit, (2) autograft, and (3) sham surgery groups. The eggs submerged in 5% acetic acid. The decalcifying membranes were cut into four pie...

Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in injury, take a role repair process by suppressing fibroblast proliferation the damaged area. It was aimed investigate effect melatonin peripheral relationship between S100 proteins angiogenic regulat...

OBJECTIVES/HYPOTHESIS Facial nerve regeneration is limited in some clinical situations: in long grafts, by aged patients, and when the delay between nerve lesion and repair is prolonged. This deficient regeneration is due to the limited number of regenerating nerve fibers, their immaturity and the unresponsiveness of Schwann cells after a long period of denervation. This study proposes to apply...

Phrenic nerve transfer is a major dynamic treatment used to repair brachial plexus root avulsion. We analyzed 72 relevant articles on phrenic nerve transfer to repair injured brachial plexus that were indexed by Science Citation Index. The keywords searched were brachial plexus injury, phrenic nerve, repair, surgery, protection, nerve transfer, and nerve graft. In addition, we performed neuroph...