Aim: To differentiate mesenchymal stem cells into functional dopaminergic neurons using an electrospun polycaprolactone (PCL) and graphene (G) nanocomposite. Methods: A one-step approach was used to electrospin the PCL nanocomposite, with varying G concentrations, followed by evaluating their biocompatibility neuronal differentiation. Results: exiguous demonstrated ideal nanotopography unpreced...

The nerve injury, whether it results in tissue loss or not, involves cutting off the nerve, making impossible for two portions to interact and, as a result, impairing functionality. Mesenchymal stem cells are one of best options cell therapy many diseases due their distinct functional properties, such potent differentiation capacity, immunomodulatory capacity and growth support. secretome gener...

Stem cells from human exfoliated deciduous teeth (SHED) are isolated from the dental pulp tissue of primary teeth and can differentiate into neuronal cells. Although SHED are a desirable type of stem cells for transplantation therapy and for the study of neurological diseases, a large part of the neuronal differentiation machinery of SHED remains unclear. Recent studies have suggested that mito...