Objective: Several phytochemical agents have been known to exhibit a neuroprotective effect. Among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. This work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...

objective(s): parkinson's disease (pd) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. evidence indicates that pd occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. it is reported that soy genistein, an estrogen agonist phytoestrogen, display neuro...

background and purpose: progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of parkinson’s disease (pd). recent studies have shown ceftriaxone, a β-lactam antibiotic, to be a neuroprotective in various neurodegenerative disorders. hence, the present study aimed to investigate the effect of ceftriaxone on behavioral disturbances of pd in an animal model. method...

Numerous basic studies have reported on the neuroprotective properties of several purine derivatives such as caffeine and uric acid (UA). Epidemiological also shown inverse association appropriate intake or serum urate levels with neurodegenerative diseases Alzheimer disease (AD) Parkinson’s (PD). The well-established mechanisms UA involve adenosine A2A receptor antagonism antioxidant activity,...

The present study explored the neuroprotective effect of Coeloglossum viride var. bracteatum extract (CE) against oxidative stress in rat cortical neurons. The results demonstrated that administration of CE inhibited hydrogen peroxide-induced neurotoxicity tested by MTT, LDH release, and TUNEL assays. We further found that CE inhibited the activation of caspase-3 (Csp3) induced by hydrogen pero...

BACKGROUND Edaravone, a free radical scavenger, has been shown to be neuroprotective in vivo and in vitro. However, the impact of small temperature variations on its neuroprotective actions remains unknown. METHODS We examined the degree of neuroprotection conferred by various concentrations of edaravone on cortical cultures exposed to prolonged hypoxia (24 h) under three conditions: mild hyp...