Many findings point to the presence of a close relationship between the immune, endocrine and neurologic systems. For example the suppressive effects of β-human chorionic gonadotropin (β-HCG) on IL-l production, the potentiative effect of enkephalins on lymphocyte functions and the suppressive effect of leuteinizing hormone (LH) on natural killer (NK) cell activities have been clearly esta...

neutrophil mobility in 60 patients with vitamin d-deficient rickets is studied, and the patients are followed after therapy by 600,000 units vitamin d. 28 of 60 patients (46%), had low chemotaxis for neutrophils before vitamin d injection (migration), and 36 of 60 (60%) had low random mobility. the results showed a significant improvement after vitamin d therapy furthermore, the level of calciu...

As the principal cellular component of the inflammatory host defense and contributor to host injury after severe physiologic insult, the neutrophil is inherently coupled to patient outcome in both health and disease. Extensive research has focused on the mechanisms that regulate neutrophil delivery, function, and clearance from the inflammatory microenvironment. The neutrophil cell membrane med...

patients afflicted by diabetes mellitus (dm) usually have more infections than those without dm. the course of the infections is also more complicated in this group of patients. one of the possible causes of increased infections prevalence is a deficiency in the immunity. besides some decreased cellular responses in vitro, no disturbances in adaptive immunity in diabetic patients have been desc...

statement of problem: patients affected with “early onset periodontitis” (eop), are not similar regarding their neutrophil deficiency and researches have yielded contradictory results in this field. purpose: the purpose of this study was to evaluate different aspects of neutrophils’ activities in peripheral blood of such patients, especially those affected with prepubertal periodontitis and juv...

conclusions the leptin can also be used for the treatment of severe and intractable l. monocytogenes and e. coli infection. results our data demonstrates that leptin is able to induce cd11b expression on neutrophils but this induction is significantly less than l. monocytogenes. indeed, cells treated with leptin had lower amounts of apoptosis compared with untreated cells. the highest amount of...

Improvements in neutrophil chemotaxis assays have advanced our understanding of the mechanisms of neutrophil recruitment; however, traditional methods limit biologic inquiry in important areas. We report a microfluidic technology that enables neutrophil purification and chemotaxis on-chip within minutes, using nanoliters of whole blood, and only requires a micropipette to operate. The low sampl...