conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

a case of palmoplantar hyperkeratosis with periodontosis and a history of recurrent severe pyoderma, pneumonia and multiple liver abscesses is described in a 12 year old girl. the patient demonstrated neutrophil dysfunction characterized by decreased random migration and chemotaxis and defective bactericidal activity. the exact immunopathological mechanism for susceptibility to infections in pa...

background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...

background coronary heart disease (chd) is the leading cause of death worldwide. research indicates that coronary atherosclerosis is the most frequent cause of chd. evidence is scarce concerning the clinical efficacy of fibrinogen or neutrophil-lymphocyte ratio (nlr) measurement in risk-stratifying patients with chronic stable angina. conclusions nlr and fibrinogen predicted cad, independent of...

hypercoagulable states are a group of conditions associated with an enhanced tendency toward blood clotting. although usual clinical manifestations of hypercoagulable states are thrombotic events such as deep venous thrombosis, hematoma can also occurs as a result of hypercoagulability in some patients. several inherited or acquired conditions may lead to hypercoagulable states. some of them in...

anti-neutrophil cytoplasmic autoantibodies have been detected in patients with some autoimmune and vascular diseases such as wegner's granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique has been employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic antibodies were seen: a cytoplasmic (...

in this study the programmed cell death (apoptosis) of human neutrophilic granulocytes was investigated in the presence and absence of fetal calf serum (fcs), cycloheximide and actinomycin-d. the results show that when fcs is omitted from cultures, apart from a decrease in viability, the percentage of apoptotic cells and dna fragmentation increases. apoptosis is accelerated in serum withdrawal ...

respiratory virus infection is a major cause of asthma exacerbation. however, the underlying mechanisms of  this exacerbation  are unknown. therefore,  to  determine  the mechanisms, we examined the effect of influenza infection in a murine model of asthma.mice were divided into four groups: the phosphate-buffered saline (pbs), house dust mite (hdm), influenza, and hdm/influenza groups. the inf...

background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...