The potential role of a new energy efficient fermentation technology has been receiving growing attention in past 4 decades. Carboxylic acids such as propionic acid, lactic acid, citric acid, tartaric acid, itaconic acid, butyric acid and nicotinic acid etc. have been used as the most efficient fermentation chemicals. This paper presents a state-of-art review on the development of the separatio...

The fluorescent derivatization of aromatic carboxylic acids by the catalytic activity of horseradish peroxidase (HRP) in the presence of excess H2O2 was investigated. Four monocarboxylic acids, nine dicarboxylic acids, and two tricarboxylic acids, all of which are non- or weakly fluorescent, were effectively converted into fluorescent compounds using this new method. This technique was further ...

5-(Trifluoromethyl)-6-(1-methyl-azepan-4-yl)methyl-1H-quinolin-2-one (TMAQ) is a novel nicotinic acetylcholine receptor (nAChR) agonist with strong selectivity for beta4-containing receptors. TMAQ also exhibits remarkable species selectivity, being a potent agonist of nAChRs containing the human beta4 subunit but having no detectable agonist activity on nAChRs containing the rat beta4 subunit. ...

objective: the aim of the present study was to elucidate the possible biochemical improving effect in lipid metabolic that may result from continuous treatment with green tea extract in normal albino rats and those rendered hyperlipidemic by long term supplementation of fat-enriched diet. materials and methods: fifty male albino rats aged six weeks with 200±10 g weight were randomly divided int...

R. A. LEWIN . . 249 The Growth of Mycobacterium tuberculosis and Mycobacterium johnei in a Modification of Dubos Medium. By R. E. GLOVER . . 251 A Comparison of a Directand a Plate-counting Technique for the Quantitative Estimation of Soil Micro-organisms. By F. A. SKINNER, P. C. T. JONES and J. E. MOLLISON . . 261 Selection of Penicillin-sensitive Mutants of Escherichia coli following Ultravio...

The connexion between pellagra and maize consumption has occupied the interest of many workers for a number of years. It has been suggested that maize owes its pellagragenic property to an imbalance of amino-acids, tryptophan being especially low. This imbalance was said to increase the need for nicotinic acid (Krehl, Henderson, de la Huerga & Elvehjem, 1946; Krehl, 1949). The presence of a ‘to...

To determine the effect of fatty acid availability on leucine metabolism, 14-h fasted dogs were infused with either glycerol or triglyceride plus heparin, and 46-h fasted dogs were infused with either nicotinic acid or nicotinic acid plus triglyceride and heparin. Leucine metabolism was assessed using a simultaneous infusion of L-[4,5-3H]leucine and alpha-[1-14C]ketoisocaproate. Leucine, alpha-...

background: some health-protecting secondary metabolites can be found at a higher concentration in the sprouts compared to other stages of plant growth. in addition, environmental stresses such as salt stress may be resulting in the increase or decrease of specific secondary metabolites in sprouts and plants. objective: evaluation the changes of trigonelline, nicotinic acid, and proline content...

fenugreek (trigonella foenum-graecum l.) has a long and respected history of medicinal uses in middle east and persian medicine. the hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin and its major alkaloid, trigonelline. the knowledge of diosgenin and trigonelline biosynthesis is derived from studies of cholesterol and nicoti...

Partial oxidation of 2-, 3and 4-picolines has received much attention because their oxidation products, picolinic acid, nicotinic acid and isonicotinic acid, respectively, are valuable intermediates of vitamins, food additives and pharmaceuticals1)~16). For example, 2-pyridinecarbaldehyde and picolinic acid are vitamins, feed stocks for synthesis of physiologically active substances, dyes and o...