background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...

The high lethality in peritonitis and the lack of data on role various NO-synthase isoforms its pathogenesis suggests advisability research to study effects (NOS) inhibitors.

Background: Pioglitazone is the selective PPAR-γ receptor agonist, which is prescribed for the treatment of type 2 diabetes and may also have antidepressant effects. Nitric oxide (NO) has been involved in some crucial roles, including learning, cognition and neurogenesis as well as some neurodegenerative diseases, including Parkinson, Alzheimer's disease (AD) and depression. Reduced estrogen le...