The aim of the present study was to investigate the effect of copper oxide nanoparticles (CuO-NPs) and copper ions (Cu++) on guppy (Poecilia reticulata), in order to assess Cu uptake in the gill, and histopathology of gill and intestinal organs in semi-static regimes for 10 days. Guppy fish were assigned into three groups; one control group, and two experimental groups receiving 20 µg/l of eith...

OBJECTIVE To measure the thickness of the crypts and quantify the number of goblet cells of the colonic mucosa with and without intestinal transit, relating them to exclusion time. METHODS Sixty Wistar rats were divided into three groups of 20 animals each according to the time of the final operation for the removal of the colon, in six, 12 or 18 weeks. In each group 15 animals underwent colo...

Cancer can significantly have ruining effects on very high of human beings, social, and economic condition. Bladder cancer has been reported as one of the most common cancers and the incidence rates of this cancer is increasing across the world. Cystectomy is a surgery to remove the urinary bladder. In the present study a part of the ileum is used instead of bladder. This study deals with mucos...

PURPOSE To determine whether the number of filled conjunctival goblet cells and mucin gene expression are altered in a mouse model of allergic conjunctivitis. METHODS A/J mice were sensitized intraperitoneally with cat dander or the peptide P3-1 from the protein Fel d1. Two weeks later, the mice were challenged for 7 consecutive days with eye drops containing the allergens. Conjunctival tissu...

The objective of this study was to provide a new insight into the origin and lineage development of mucus-producing cells in the small intestinal crypt. For this, new experimental data were obtained from both crypt sections and whole mounts. Model simulation studies were undertaken to investigate which rules are most likely to govern the dynamic cellular development and goblet cell pedigree. We...

Goblet cell metaplasia is an important morphological feature in the airways of patients with chronic airway diseases; however, the precise mechanisms that cause this feature are unknown. We investigated the role of endogenous platelet-activating factor (PAF) in airway goblet cell metaplasia induced by cigarette smoke in vivo. Guinea pigs were exposed repeatedly to cigarette smoke for 14 consecu...