We report a case of a 6-week-old infant with diabetes mellitus based on a genetic defect in the sulfonylurea receptor 1 (SUR1), an ATP-sensitive potassium (KATP) channel protein. A spectacular improvement in glucose regulation was shown by real-time continuous glucose monitoring when switching her from insulin to oral glibenclamide. Children with neonatal onset of diabetes deserve genetic testi...

in biaxially strained p-mosfet with si channel, formation of a parasitic parallel channel due to misalignment of energy bands degrades device performance by increasing off-state current. in this paper a new approach has been introduced to eliminate this parasitic channel by increasing the dopant concentration of virtual substrate up to . using simulation the impact of this method on the parasit...

zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. the efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of na+ and make depolarization na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. also it is an effective blocker of one subtype of tetrodoxine (...

introduction atrial standstill is a rare condition, characterized by absence of atrial electrical and mechanical activity evident in surface electrocardiography echocardiography, or fluoroscopy, which is associated with unresponsiveness of atria to maximal output electrical stimulation. this condition can be present with thromboembolic complication, low cardiac output, and sometimes palpitation...

Automatic detection of different oral-nasal configurations during speech is useful for understanding normal nasalization and assessing certain speech disorders. We propose an algorithm to extract nasalization features from dual-channel acoustic signals that are acquired by a simple two-microphone setup. The feature is based on a dual-channel acoustic model and the associated analysis method. We...

background and aims. helicobacter pylori is a microaerophilic gram-negative spiral organism. it is recognized as the etiologic factor for peptic ulcers, gastric adenocarcinoma and gastric lymphoma. recently, it has been isolated from dental plaque and the dorsum of the tongue. this study was designed to assess the association between h. pylori and oral lesions such as ulcerative/inflammatory le...

Introduction: Verapamil, a phenylalkylamin –type Ca2+ channel blocker, is widely used in the treatment of cardiovascular disorders especially as an antiaryhthmic and antiangina agent. Theoretically, calcium can influence thyroid function and there are evidences that Ca2+ channel blockers are able to interfere with thyroid function. In this study, the effects of chronic oral administration of...