Low-density-lipoprotein (LDL) oxidation may provide the crucial link between plasma LDL and atherosclerotic-lesion formation. Oxidation can be induced in vitro by incubating LDL with cells or metal ions and can be measured by continuously monitoring conjugated-diene absorbance at 234 nm. Measurement of LDL oxidizability was improved by performing the assay with 0.05 g of LDL-protein per liter o...

A comparison is made of the antioxidant activity of a water-soluble form of alpha-tocopherol complexed with bovine serum albumin (alpha-T X BSA) with that of micellar alpha-tocopherol and aqueous 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate (Trolox) to inhibit autoxidation of linoleic acid in sodium dodecyl sulfate micelles. The peroxyl radical trapping ability of alpha-T X BSA compares f...

Background: Although there is substantial evidence for antioxidant effects of individual nutrients, such as vitamins C and E, little research has been done to show the antioxidant efficacy of nutritionally complete micronutrient supplements. Objective: This study examined whether a comprehensive multivitamin/mineral supplement (MVMS; LifePak) improves antioxidant status and resistance to LDL ox...

Hypercholesterolemia is associated with impairment of endothelial function due to increased levels of LDL. In diabetic patients, however, attenuation of endothelial function occurs even under normocholesterolemic conditions. Here we assessed whether glycation of LDL potentiates their influence on endothelial function, with particular emphasis on the oxidizability of LDL and the role of O2-. Hum...

OBJECTIVE: Oxidative stress is a serious complication in diabetic patients. Black tea and also sour tea contained some flavonoids with antioxidant properties and may be helpful in prevention of lipid oxidation. The aim of this study was to compare the effects of sour tea and black tea on in-vitro copper induced serum lipids oxidizability in diabetic patients. MATERIALS AND METHODS: In this se...

The intake of antioxidants intake has been reported to be inversely associated with the incidence of coronary artery disease. To clarify the possible role of lipophilic antioxidants in prevention of atherosclerosis, we investigated the effects of lycopene on the susceptibility of low-density lipoprotein (LDL) to oxidative modification. In this study, “lycopene” was added to plasma and incubated...

kingdom, is believed to play a preventive role in the development of certain diseases associated with free radical-induced damage in the body. The high sensitivity of flavonoids to react with free radicals makes them pharmacological effective. Flavonoids and their ability to inactivate superoxide anion radicals (O2· ) have been studied for about a decade. Flavonoids are most likely to react wit...

antioxidant consumption has been reported to be inversely associated with the incidence of coronary artery disease. to clarify the possible role of vitamin e and volatile oils in the prevention of atherosclerosis, the effects of these compounds on the susceptibility of low-density lipoprotein (ldl) to oxidative modification were investigated. in this study, vitamin e and seven volatile oils “an...