Two modes of vesicular release of transmitter occur at a synapse: spontaneous release in the absence of a stimulus and evoked release that is triggered by Ca2+ influx. These modes often have been presumed to represent the same exocytotic apparatus functioning at different rates in different Ca2+ concentrations. To investigate the mechanism of transmitter release, we have examined the role of sy...

0950-5849/$ see front matter 2009 Elsevier B.V. A doi:10.1016/j.infsof.2009.06.005 q This research was supported by the MKE (Minis Korea, under the ITRC (Information Technology Resea supervised by the IITA (Institute of Information Tech 2007-(C1090-0801-0032). * Corresponding author. Tel.: +1 972 883 6619; fax E-mail address: [email protected] (W.E. Wong) Existing methods for testing an SDL sp...

In brain slice preparations of thalamocortical neurons with TTX, APV, CNQX, DNQX, and cesium present, spontaneous miniature inhibitory postsynaptic current (GABA mIPSCs) amplitudes are widely varying (5-80pA), with a skewed distribution. In computational models of reconstructed thalamocortical neurons, with the same currents blocked but without intra-synaptic variables, mIPSC amplitudes are nar...

Patterns of spontaneous activity are valuable reflections of well-being in animals and humans and, because of this, investigations have frequently incorporated some form of activity monitoring into their studies. It is widely believed that activity monitoring, alongside assessments of general behaviour, should be included in initial CNS safety pharmacology screening. As the number of marmoset s...

Objective: T h e mortality for men is not only greater than that of women as indicated by the life expectancy but of the five leading cause of death in the nation (malignant neoplasms; cerebrovascular disease; heart disease; diabetes mellitus and homicides), the rates for men were greater in four (malignant neoplasms; cerebrovascular; hea rt d is e a se and homicides). Despite these realities ,...

In this study, the relationship among four species of Polygonum (including P. hyrcanicum (three samples), P. persicaria, P. avicular, and P. hydropiper) was investigated by GC profiling. Furthermore, the major compounds of the ethylic ether extract of P. hyrcanicum were identified by GC/MS as: α-bisabolol (17.5%), cedrol (15.9%), sesquisabinene hydra...