Brain Computer Interfaces (BCI) provide a non-muscular communication channel for people with severe motor impairment. The most commonly used BCI for communication is the so called P300-Speller that received its name from the event-related potential (ERP) P300 which is elicited by the speller (oddball) paradigm. Several researchers reported that it is not only the P300 but also other ERPs that a...

Evaluation of cognitive functions in Parkinson’s patients without dementia with auditory event related potential (P300) Objective: Idiopathic Parkinson’s disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system. As the disease progresses over time, depression, cognitive dysfunction and alterations in co...

BACKGROUND Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respective...

INTRODUCTION As endophenotypes bridge the gap between genetics and phenotypic disease expression, identifying reliable markers is important for fostering understanding of pathophysiology. The present aim was to conduct current meta-analyses of 3 key auditory event-related potential (ERP) components that have been held as potential endophenotypes for schizophrenia: P50, P300 amplitude and latenc...

In this paper we explore the use of evolutionary algorithms in a wrapper-based selection of features and the classification of P300 signals in Brain Computer Interfaces. In particular we focus on a paradigm that uses the P300 potential associated to particular visual stimuli for hands free text entering. In our experiments the GA has found new ways to process and combine EEG signals to improve ...

BACKGROUND P300 and steady-state visual evoked potential (SSVEP) approaches have been widely used for brain-computer interface (BCI) systems. However, neither of these approaches can work for all subjects. Some groups have reported that a hybrid BCI that combines two or more approaches might provide BCI functionality to more users. Hybrid P300/SSVEP BCIs have only recently been developed and va...

BACKGROUND The P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function). This paper reviews the development of the auditory P300 across the lifespan. METHODOLOGY/PRINCIPAL ...

In a yeast two-hybrid screen to identify proteins that bind to the KIX domain of the coactivator p300, we obtained cDNAs encoding nucleosome assembly protein 1 (NAP-1), a 60-kDa histone H2A-H2B shuttling protein that promotes histone deposition. p300 associates preferentially with the H2A-H2B-bound form of NAP-1 rather than with the unbound form of NAP-1. Formation of NAP-1-p300 complexes was f...