the p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms.the transcription factor p63 is a homologue of the tumor suppressor p53. unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63, , is transcribed from two different promoters giving rise...

P53 tumor suppressor gene, also known as “genome guardian” is mutated in more than half of allkind of cancers. In this study we have investigated the controls of environmental pH for P53 genemutation in point of specific sequence which is prone to mutagenesis. The most probable cancerousmutations occur as point mutations in exons 5-8 of P53 gene. The 175th codon of P53 is the thirdmost mutated ...

Our previous studies have illustrated that CacyBP/SIP (Calcyclin-binding protein or Siah-1-interacting protein) promoted the proliferation of glioma cells. However, possible mechanism still needs to be clarified. In current study, we aimed uncover potential in regulating cell proliferation. We found decreased level p53, but not mRNA p53 mutant U251 line, whereas, wild-type U87 neither its nor r...

The goal of this study was to clarify the role p16INK4a, p14ARF, and p53 protein expressions in carcinogenesis squamous cell carcinomas lip. p53, p14ARF proteins were examined 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases carcinoma lip, 14 actinic cheilitis, 13 normal mucosa. Immunoreactivity peritumoral epithelium adjacent als

biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and ki67 is a nuclear protein involved in proliferation process. stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. in this case-control study we evaluated 50 patients with non small cell lung cancer, co...

sirtuin1 (sirt1) is an enzyme that deacetylates histones and several nonhistone proteins including p53 during stress and plays an important role in the survival of tumor cells. hereby, this study describes the potency of salermide as a sirt1 inhibitor to induce apoptosis in the mcf-7 and mrc-5 cell lines. mcf7 and mrc-5 cell lines were cultured in rpmi-1640 and treated with or without salermide...

ABSTRAK
 Astrositoma merupakan salah satu tumor primer susunan saraf pusat yang paling sering ditemukan dibandingkan lainnya. Tujuan penelitian ini adalah untuk mengetahui pola ekspresi protein P53 pada astrositoma berdasarkan derajat histopatologi. Penelitian observasi analitik dengan pendekatan cross sectional dilakukan di Fakultas Kedokteran Universitas Hasanuddin Makassar mulai bulan A...

background and objective: p53 is a suppressive gene that plays a key role in dna repair and apoptosis. the purpose of this study was to investigate the effect of p53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (scc) response to neoadjuvant chemoradiotherapy. patients and methods: in this retrospective cohort study, 44 patients with loca...

Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (SCC) response to neoadjuvant chemoradiotherapy. Patients and Methods: In this retrospective cohort study, 44 patients with loc...

Elevated cAMP levels in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells attenuate the doxorubicin-induced p53 accumulation and protect cells against apoptosis. cAMP responsive element binding protein (CREB) is a cAMP-stimulated transcription factor that regulates genes whose deregulated expression cooperatein oncogenesis. In the present study, we investigated the role of CREB on i...