Major attention has been focused on dendrimer-DNA complexes because of their applications in gene delivery systems. Dendrimers are also used to transport miRNA and siRNA in vitro. We examine the interaction of tRNA with several dendrimers of different compositions, mPEG-PAMAM (G3), mPEG-PAMAM (G4), and PAMAM (G4) under physiological conditions using constant tRNA concentration and various dendr...

some organic molecules can be isomerized upon photoirradiation and when accompanied by a change in the visible absorption spectrum, it is called photochromism. azobenzenes are important part of molecular machines and nanotechnology, which are this phenomenon is called photoisomerization azobenzene (azo) chromophores , and have been incorporated into a wide variety of materials and molecular arc...

Some organic molecules can be isomerized upon photoirradiation and when accompanied by a change in the visible absorption spectrum, it is called photochromism. Azobenzenes are important part of molecular machines and nanotechnology, Which are This phenomenon is called photoisomerization Azobenzene (azo) chromophores , and have been incorporated into a wide variety of materials and molecular arc...

A method to functionalize cholecyst-derived extracellular matrix (CEM) with free amine groups was established in an attempt to improve its potential for tethering of bioactive molecules. CEM was incorporated with Generation-1 polyamidoamine (G1 PAMAM) dendrimer by using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide and N-hydroxysuccinimide cross-linking system. The nature of incorporation of P...

Correction for ‘Describing the adsorption of doxorubicin on a PAMAM dendrimer by ab initio calculations’ Handriela Hoff de Oliveira Sobrinho et al. , Mol. Syst. Des. Eng. 2023, https://doi.org/10.1039/d3me00060e.

BACKGROUND Cystic Fibrosis (CF) is a genetic disorder caused by mutation(s) in the CF-transmembrane conductance regulator (Cftr) gene. The most common mutation, ΔF508, leads to accumulation of defective-CFTR protein in aggresome-bodies. Additionally, Pseudomonas aeruginosa (Pa), a common CF pathogen, exacerbates obstructive CF lung pathology. In the present study, we aimed to develop and test a...

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

Polyamidoamine (PAMAM) dendrimers have gained so much attention for drug and gene delivery since they have been introduced decades ago. The internal cavities and multivalent surface groups of PAMAM dendrimers have been widely used for small-molecule drugs/biomacromolecules encapsulation and conjugation. The involvement of PAMAM dendrimers in drug delivery systems (DDSs) has significantly improv...

Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available. Both have different properties, mainly based on their different overall charges at physiological pH. Currently, an important function of dendrimers as carriers of short single-st...

Nanotechnology is an important and emerging industry with a projected annual market of around one trillion US dollars by 2011-2015. Concerns about the toxicity of nanomaterials in humans, however, have recently been raised. Although studies of nanoparticle toxicity have focused on lung disease the molecular link between nanoparticle exposure and lung injury remained unclear. In this report, we ...