OBJECTIVE Diabetes may influence the outcome of complicated peptic ulcer disease, due to angiopathy, blurring of symptoms, and increased risk of sepsis. We examined whether diabetes increased 30-day mortality among Danish patients hospitalized with bleeding or perforated peptic ulcers. RESEARCH DESIGN AND METHODS This population-based cohort study took place in the three Danish counties of No...

OBJECTIVE To study the characteristics of peptic ulcer and erosion in pediatric patients. METHODS Over a period of seven years, 1,026 children underwent upper gastrointestinal endoscopy in our pediatric gastroenterology unit. RESULTS Peptic ulcers and erosions were found in 59 (7.2%) patients [ulcers in 42 (5.1%)and erosions in 17 (2.1%)]. Thirty (50.9%) children presented with acute upper ...

Peptic ulcer bleeding is an important complication of peptic ulceration. The condition carries significant morbidity and mortality despite advances in both endoscopic intervention techniques and pharmacological treatment. About one third of patients have a recurrence of bleeding within a few years of discharge. Before Helicobacter pylori was discovered, most of these patients were given mainten...

The ingestion of non-steroidal anti-inflammatory drugs (NSAID) in 272 patients with bleeding or perforated peptic ulcer was compared with 272 age/sex matched controls. A significantly higher proportion of patients with gastric ulcers had received NSAID than those with duodenal ulcers. Twelve of 90 (13%) patients admitted with bleeding duodenal ulcers had received NSAID compared with 11 of 26 (4...

Peptic ulcers are common although the pattern of aetiology is changing. The traditionally most frequent causes of Helicobacter pylori infection and non-steroidal anti-inflammatory toxicity are likely to assume less relative importance as the proportion of cases attributed to other causes rises. Primary care physicians should be aware the pathogenesis of peptic ulceration in non-H. pylori non-NS...

Peptic ulcer is a chronic disease affecting up to 10% of the world’s population. The formation peptic ulcers depends on presence gastric juice pH and decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) Helicobacter pylori (H. pylori) infection are two major factors disrupting resistance injury. Conventional treatments ulcers, such as proton pump inhibitors (PPIs) histam...

Gastric Helicobacter The discovery of the association of Helicobacter pylori with gastritis, peptic ulcers, and gastric neoplasia has led to fundamental changes in the understanding of gastric disease in humans. Investigation of the relationship of gastric disease to Helicobacter spp. in other animals has resulted in the discovery of H. mustelae in ferrets with gastritis and peptic ulcers, H. a...