Moderate-to-severe chronic periodontitis results in clinical loss of attachment, reduced width of attached gingiva (AG), periodontal pockets beyond mucogingival junction (MGJ), gingival recession, loss of alveolar bone, and decreased vestibular depth (VD). The encroachment of frenal and muscle attachments on marginal gingiva increases the rate of progression of periodontal pockets, prevents hea...

OBJECTIVE To evaluate if there is a relationship between findings of carotid artery calcification (CAC) and periodontal risk in nonsmoker subjects by using panoramic radiographs (DPR). MATERIALS AND METHODS A total of 1146 DPRs were investigated. Gender, age, severity of bone loss, tooth loss, periodontal risk, and findings of carotid calcification were recorded. The periodontal risk was eval...

background and aims. considering the importance and prevalence of cardiovascular disease and periodontal disease, the aim of this study was to compare the amount of periodontal destruction in patients with coronary heart disease (chd) and healthy controls, using panoramic radiography. materials and methods. fifty-four individuals (27 patients with chd and 27 patients without chd) participated i...

Objective: Leukocyte adhesion deficiency(LAD) is a scarce, autosomal recessive inherited disorder . LAD-I which is the most common type occurs due to mutations on the CD18 gene. This mutation leads to absence or severe reduction of leukocyte cell surface expression of ß2 integrin molecules which are necessary for the adhesion of the leukocytes to the endothelial cells, transendothelial mi...

In periodontal disease, host recognition of bacterial constituents, including lipopolysaccharide (LPS), induces p38 MAPK activation and subsequent inflammatory cytokine expression, favoring osteoclastogenesis and increased net bone resorption in the local periodontal environment. In this paper, we discuss evidence that the p38/MAPK-activated protein kinase-2 (MK2) signaling axis is needed for p...

The loss of alveolar bone, which is very often a consequence of long-lasting inflammation of dental tissue, usually results in loose teeth and eventually the loss of the affected teeth. Removing the causes of periodontal disease with periodontal treatment can stop further alveolar bone decay, however, the problem remains unsolved of how to fix an affected tooth that has more than half of its ro...

background: cyclosporin a (csa) is a known immunosuppressive agent and can be considered as a lifesaving drug in the organ transplantation cases. however, it is associated with many side-effects on different tissues and body organs including the periodontal tissues. the present animal study was undertaken to evaluate the effects of csa targeting the tissue triad of periodontal tissues, i.e., gi...