a 29- year old female with bone pain and history of precocious puberty was referred for bone scintigraphy. on physical examination café au lait macular spots were noted on her neck, buttocks and left leg. bone scan showed multiple areas of intense increased activity which was in favour of polyostotic fibrous dysplasia. considering the presence of polyostotic fibrous dysplasia, precocious pubert...

Appearance of secondary sexual characteristics before 9 years of age in boys constitutes precocious puberty(l). There are three major types of sexual precocity: true or central, peripheral and combined peripheral and central. Precocious puberty may be isosexual or heterosexual in nature. In this communication we report a case of meningomyelocele who developed isosexual precocious puberty second...

OBJECTIVES This review was aimed at determining the imaging findings in patients with precocious puberty. RESULTS Within a period of 8 years (from 2002 to 2010) there were 53 patients diagnosed with precocious puberty. Out of the 53 patients, 37 had undergone diagnostic imaging to detect the possible organic causes of precocious puberty. Imaging findings were positive in 31 patients and out o...

BACKGROUND Central precocious puberty (CPP) is characterized as increasing gonadotropin-releasing hormone (GnRH) release. Orexin-A has also been shown to affect GnRH release. However, there are few reports about the effect of orexin A on the treatment of CPP. METHODS After establishing the precocious puberty model, the rats were divided into four groups: normal control, precocious puberty rat...

We report a girl with a de novo distal deletion of 9p affected by idiopathic central precocious puberty and intellectual disability. Genome-wide array-CGH revealed a terminal deletion of about 11 Mb, allowing to define her karyotype as 46; XX, del(9)(p23-pter). To our knowledge, this is the second reported case of precocious puberty associated with 9p distal deletion. A third case associates pr...

We report the first case of central precocious puberty in a patient with 48,XXYY Klinefelter syndrome variant. We also report clinical characteristics, growth pattern, endocrine data and pathological testicular findings. The patient did not receive medical care for his precocious pubertal development, because of adequate height prognosis, and reached normal height for both his target height and...

Immature Glycine max (L.) Merrill seeds were grown and matured in liquid medium at 25 degrees C under fluorescent light. In standard medium containing minerals, 146 millimolar sucrose and 62.5 millimolar glutamine (osmolality 0.24), precocious germination seldom occurred with a starting seed size of less than 300 milligrams fresh weight. Frequency of precocious germination increased with increa...