نتایج جستجو برای: premature chromosome condensation
تعداد نتایج: 202062 فیلتر نتایج به سال:
A radiation-sensitive fibroblast culture (180BR) established from an acute lymphoblastic leukemia patient who died following radiotherapy is defective in the repair of radiation-induced DNA double-strand breaks. The cells also show a reduced capacity to repair interphase chromosome damage visualized by means of premature chromosome condensation and metaphase chromosome aberrations measured by f...
Microcephalin (MCPH1) is a gene mutated in primary microcephaly, an autosomal recessive neurodevelopmental disorder in which there is a marked reduction in brain size. PCC syndrome is a recently described disorder of microcephaly, short stature, and misregulated chromosome condensation. Here, we report the finding that MCPH1 primary microcephaly and PCC syndrome are allelic disorders, both havi...
B iological dosimetry of ionizing radiation is generally performed by scoring dicentrics and/or translocations in chromosome from peripheral blood lymphocytes (pbl) at the first mitosis following in vitro growth stimulation. It is well known that after irradiation, in this procedure mitotic index is low in some individuals, so the scored mitoses might not be representative of the exposed cell p...
Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome). The gene encodes the BRCT-domain containing protein microcephalin/BRIT1. Apart from its role in the regulation of chromosome condensation, the protein is involved in the cel...
Premature Chromosome Condensation (PCC) has been shown to be a powerful cytogenetic and cytokinetic tool in understanding cell-cycle analysis(1) and also for diagnostic purposes(2,3). Although PCC is a useful cytogenetic tool, it involves somatic cell hybridizations employing a mitotic partner. Understanding of the factors responsible for chromatin condensation and their mechanism of action can...
Condensins I and II are multisubunit complexes that play essential yet distinct functions in chromosome condensation and segregation in mitosis. Unlike condensin I, condensin II localizes to the nucleus during interphase, but it remains poorly understood what functions condensin II might have before mitotic entry. Here, we report that condensin II changes its chromatin-binding property during S...
Primary microcephaly is an autosomal recessive disorder characterized by marked reduction in human brain size. Microcephalin (MCPH1), one of the genes mutated in primary microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry. Additionally, MCPH1 ensures the proper temporal activation of chromosome condensation during mitosis, by acting as a negative regulator o...
Ionizing radiation-induced foci (IRIF) of DNA repair-related proteins accumulated at DNA double-strand break (DSB) sites have been suggested to be a powerful biodosimetric tool. However, the relationship between IRIF induction and biologically relevant endpoints, such as cell death and formation of chromosome rearrangements is less clear, especial...
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