premature chromosome condensation (pcc) appears to have a possible utility for biological dosimetry purposes. the pcc technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. for this purpose, human blood samples were exposed in vitro to 60co up to 10 gy and the pcc technique was performed immediately after irradiation. anal...

background: irradiation is one of the major causes of induced sperm dna damage. various studies suggested a relation between sperm dna damage and fertilization rate after intra-cytoplasmic sperm injection (icsi). objective: in this study, fertilization rate and premature chromosome condensation (pcc) formation after icsi of hamster oocytes with irradiated sperms from normal and oligosperm indiv...

Premature chromosome condensation (PCC) has previously been observed in tissue culture and is believed to arise from asynchronous mitotic activity in multinucleated cells in which the affected nucleus is in interphase and at least one nucleus is in metaphase. Such cells have been noted following fusion induced by virus infection, spontaneously, and after treatment with cytochalasin B. The pheno...

between the cytotoxic effects of these agents and the incidence of chromosome aberrations in the treated cells (2,4, 15). However, BLM treatment severely inhibits the progression of cells into mitosis. The probability that the extensively damaged cells might not be reaching mitosis makes it difficult to assay the chromosome damage accurately by the conven tional techniques. Recently, we have sh...