The nature of the control of hippocampal formation field activity [theta (4) and large-amplitude irregular activity (LIA)] and &on/B-off cell discharges by an ascending hypothalamoseptal pathway was investigated in urethane-anesthetized rats. Electrical stimulation of the dorsomedial-posterior hypothalamus in the range of 0.1-l .O mA in 0.1 -mA steps produced 13 in the hippocampal formation, wi...

Paired specimens of cerebrospinal fluid and serum were taken from 21 patients to estimate penicillin concentrations two to three hours after the last dose of a course of 14-21 daily intramuscular injections of procaine penicillin 0.6 MU. Of 10 patients treated with procaine penicillin alone, eight had no detectable penicillin and two had sub-treponemicidal concentrations (less than 0.018 mg/l) ...

The transfer of procaine and lignocaine from blood to cerebrospinal fluid (c.si.) was studied in six patients and in twelve dogs. Local anaesthetics appeared very rapidly in the c.s.f. after intravenous administration. Within 20 minutes, a c.s.f./plasma ultrafiltrate ratio around 0.9 was reached. Para-aminobenzoic acid, a procaine metabolite, appeared in c.si. later than procaine. This is expla...

The effects of the two local anesthetics tetracaine and procaine and a quaternary amine derivative of lidocaine, QX314, on sarcoplasmic reticulum (SR) Ca2+ release have been examined by incorporating the purified rabbit skeletal muscle Ca2+ release channel complex into planar lipid bilayers. Recordings of potassium ion currents through single channels showed that Ca(2+)- and ATP-gated channel a...

or quinidine. Two dose schedules were employed; procaine amide, 3.0 and 6.0 g daily and quinidine, 1.2 and 1.8 g daily. Though adequate and even high drug blood levels were reached, an effective antiarrhythmic response was observed in only eight patients receiving procaine amide and in seven of those taking quinidine. These modest successful results were associated with a high incidence of trou...

The effect of procaine hydrochloride, an anesthetic known to alter membrane structure, on the induced formation of alkaline phosphatase, a periplasmic enzyme, in Escherichia coli was investigated. Procaine hydrochloride specifically arrested the appearance of active alkaline phosphatase while permitting the induction of another enzyme, beta-galactosidase, which is internally localized. Evidence...

The drug sensing properties of procaine and berberine drug sensors based on ruthenium dioxide thin film were investigated. Ruthenium dioxide (RuO₂) membrane prepared using a sputtering method was used as substrates for the drug sensors. The procaine and berberine drug sensors were prepared using a drug-sensitive membrane that measured the procaine and berberine concentration in a linear range f...

The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increase...