1. The effects of several phenothiazine derivatives on lipid-peroxidation systems in rat liver microsomes were studied and the results are considered in relation to the hepatotoxic action of carbon tetrachloride. 2. The lipid-peroxidation system coupled to NADPH(2) oxidation and stimulated by an ADP-Fe(2+) mixture is strongly inhibited in vitro by promethazine (50% inhibition at 29mum). Chlorpr...

INTRODUCTION Both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations. Therefore, this study aimed to compare midazolam with midazolam-promethazine regarding induction, maintenance, and recovery characteristics following pediatric pr...

background: laparoscopic gastric plication (lgp) is a technique in the restrictive category of bariatric procedures that reduces the gastric volume. nausea and vomiting are the most common complications after this procedure. the goal of this research is to determine the preventive effective dose of promethazine on postoperative nausea and vomiting after laparascopic gastric placation methods: a...

objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...

Introduction: To improve our understanding of dizziness, its assessment, as well as its management to identify the appropriate treatment in order to reduce the costs and to increase the patients’ quality of life. Methods: A single blind parallel group randomized controlled trial was conducted on 164 participants with dizziness. One group received 25mg/ml promethazine and another received 5mg/ml...

Previous work has left unresolved questions on whether promethazine reduces the sensation of breathlessness. This study was designed to provide a definitive answer and to determine the contributions from promethazine's major pharmacological actions. Twelve healthy subjects participated in a double-blind, within-subject comparison of promethazine and placebo each given acutely by mouth. Breathle...