Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...

Purpose: To evaluate colostrum total protein differences between left and right breasts and between mothers of boy and girl infants. Materials and Methods: A cross sectional study for delivery was carried out on 30 boy-delivered and 30 girl-delivered mothers aged 16 to 36 years, conducted at the Izadi and Al-Zahra Hospitals in Qom city, Iran. Colostrum was collected from both breasts by man...

in recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. although, the objective of this study was to achieve smaller chitosan nano carriers via changing fabrication parameters such as ph and temperature and ...

Abstract Protein coronae formed with nanoparticles confer several useful properties. However, the non‐specific nature of protein corona formation makes it difficult to deliver specific proteins for therapeutic applications. Herein, we report on construction a new type corona, termed binding‐mediated corona. This enables efficient and controllable delivery functional proteins, which is otherwise...

More effective and tailored drug delivery systems (DDS) are continuously investigated, tested, and, eventually, marketed. In the last 30 yr, the pharmaceutical industry has made substantial steps in this direction. Drug products containing proteins and peptides, as therapeutic agents, are a perfect example of these two intimately correlated aspects: route of administration and quality of life. ...