Collybistin (CB) is a guanine nucleotide exchange factor (GEF) selectively localized at GABAergic and glycinergic postsynapses. Analysis of mRNA shows that several isoforms collybistin are expressed in the brain. Some have SH3 domain (CBSH3+) some no (CBSH3?). The CBSH3+ mRNAs predominantly over CBSH3?. However, an immunoblot study mouse brain homogenates, only protein were detected, proposing ...

the p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms.the transcription factor p63 is a homologue of the tumor suppressor p53. unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63, , is transcribed from two different promoters giving rise...

Abstract Glioblastoma multiforme (GBM) is a lethal primary brain cancer with median survival of 14.6 months despite standard treatment maximal surgical resection, radiotherapy, and temozolomide (TMZ). Recent research has identified PIK3CB/p110β as the most important regulator AKT activation GBM cell survival. Utilizing pharmacogenomic databases Genomics Drug Sensitivity in Cancer (GDSC) Cell Li...

The diversity of protein isoforms arising from alternative splicing is thought to modulate fine-tuning of synaptic plasticity. Fragile X mental retardation protein (FMRP), a neuronal RNA binding protein, exists in isoforms as a result of alternative splicing, but the contribution of these isoforms to neural plasticity are not well understood. We show that two isoforms of Drosophila melanogaster...

Haplolethals (HL) are regions of diploid genomes that in one dose fatal for the organism. Their biological meaning is obscure because heterozygous loss-of-function mutations result dominant lethality (DL) and, consequently, should be under strong negative selection. We report an depth study HL associated to gene wings up A ( wupA ). It encodes 13 transcripts (A-M) yield 11 protein isoforms (A-K...

In subprimates, a single form of tyrosine hydroxylase (TH) is expressed, whereas two TH protein isoforms have been identified in monkeys and four isoforms have been demonstrated in humans. In order to establish the evolutionary pattern/emergence of these multiple TH isoforms, adrenal medullae from different mammalian species were analyzed by blot immunolabeling using pan-specific TH antibodies ...