In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficientl...

Solid-liquid equilibria of solid mixtures in compressed CO2 are very important in assessing the feasibility of gas-assisted micronization processes such as PGSS (Particles from Gas-Saturated Solution). The determination of solid-liquid transition temperatures, the eutectic temperature and the associated composition of the melt can be problematic and time-consuming. Such data are required in the...

One of the most important environmental concerns for the polymer industry is to produce new products with near-zero residual monomer content. A new process based on supercritical CO2 has been successfully tested for the extraction of the residual monomer and the simultaneous micronization of the polymer. The process has been tested on a pilot-scale plant. The reduction of methyl methacrylate (M...

Two experiments were conducted to determine the effects of micronization (infrared heat treatment), dehulling, or enzyme supplementation on the nutritive value of three cultivars (Impala, Radley, and Sirius) of peas in laying hens. In Experiment 1, 280 White Leghorn hens were fed diets containing micronized and dehulled peas for a period of 12 wk. The dietary inclusion of peas was 600 g/kg (cor...