Oxidative stress is defined as an imbalance between the antioxidant defense system and production of reactive oxygen species (ROS). At low levels, ROS are involved in regulation redox signaling for cell protection. However, upon chronical increase oxidative stress, damage occurs, due to protein, DNA lipid oxidation. Here, we investigated modifications myofilament proteins, their role modulating...

Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of genistein on proteins involved in β-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat. Materials and Methods: We used three-month-...

Abstract Protein homeostasis is modulated by stress response pathways and its deficiency a hallmark of aging. The integrated (ISR) conserved stress-signaling pathway that tunes mRNA translation via phosphorylation the initiation factor eIF2. ISR activation are finely balanced eIF2 kinases guanine nucleotide exchange eIF2B. However, role during aging remains poorly understood. Using genomic muta...

tau is one of several types of microtubule-associated proteins (maps), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses, abe...

Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...

Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. loss of protein associates tumor metastasis and poor survival GC patients. During progression, an aberrantly elevated miR-20a-5p expression has been found, which induces phosphorylation, t...

ABSTRACT Animal steroid hormones initiate signaling by passive diffusion into cells and binding to their nuclear receptors regulate gene expression. can via G protein-coupled (GPCRs); however, the underlying mechanisms are unclear. Here, we show that a newly discovered ecdysone-responsive GPCR, ErGPCR-3, transmits hormone 20-hydroxyecdysone (20E) signal 20E promoting its entry in lepidopteran i...

objective(s):cyclophosphamide (cp) toxicity on testis was hampered by squid ink polysaccharide (sip) via restoration of antioxidant ability in our previous investigations. this study investigated roles of nrf2/are signal pathway in testis of treated mice. materials and methods: male kunming mice were employed to undergo treatment with sip and/or cp. protein levels of nrf2, keap-1, histone deace...