the effects of chronic administration of lithium, on acute toxicity of carbamazepine (cbz) in mate albino mice was studied and the ld50 values were determined from dose-probit curves. the results showed that in lithium pretreated animals (animals consumed drinking water contraining 600 mg/l lithium carbonate for 10 days) the ld50 value (the doese corresponding to probit 5) of cbz decreased sign...

introduction it has long been known that ionizing radiation can lead to detrimental effects in normal cells. in this light, radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. this study aimed to evaluate the radio-protective effect of n-acetylcysteineagainst radiation-induced mortality in male mice. materials and methods 52 healthy male m...

We studied the combined effects of local irradiation on in vivo partially synchronized solid mouse tumors. Syngeneic fibrosarcoma cells were transplanted s.c. into the thighs of C3H/He mice. When the tumors grew to 179 cu mm in volume, 1-beta-D-arabinofuranosylcytosine (ara-C) was repeatedly injected i.p. followed by a single injection of vinblastine sulfate at 5 hr after the end of the ara-C t...

Dihydroxyanthraquinone (DHAQ; NSC 279836) is a recently synthesized compound that is structurally similar to Adriamycin and produces greater antitumor effects in murine model sys tems. We compared DHAQ to Adriamycin in rats, with and without irradiation of the chest at various intervals after drug treatment. A single injection of Adriamycin (1 mg/kg i.p.) had little effect on animal survival, e...

We studied the combined effects of local irradiation on in vivo partially synchronized solid mouse tumors. Syngeneic fibrosarcoma cells were transplanted s.c. into the thighs of C3H/He mice. When the tumors grew to 179 cu mm in volume, 1-/?-D-arabinofuranosylcytosine (ara-C) was repeatedly in jected i.p. followed by a single injection of vinblastine sulfate at 5 hr after the end of the ara-C tr...

Steady-state hematopoiesis is sustained through differentiation balanced with proliferation and self-renewal of hematopoietic stem cells (HSCs). Disruption of this balance can lead to hematopoietic failure, as hematopoietic differentiation without self-renewal leads to loss of the HSC pool. We find that conditional knockout mice that delete the transcriptional repressor NKAP in HSCs and all hem...

Genomic DNA stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. These organisms are supposed to possess spec...