Objective: The purpose of this study was to examine discrepancies in the standard method for determining the radiochemical purity (RCP) of mTc-exametazime. The package insert for mrc-exametazime indicates that the entire RCP testing procedure requires approximately 15 min to complete, although the solvent-developing time for the three-paper chromatography system is described to be s 1 00 sec. A...

  Introduction: Radioimmunotherapy (RIT) is a very promising new therapy for the treatment of recurrent B-Cell non-Hodgkin's lymphoma (NHL). Iodine-131 is the most frequently used nuclide in clinical RIT, but its usefulness has been limited by dehalogenation of monoclonal antibodies labeled via conventional methods. To circumvent this problem, we have synthesized a tr...

Background: In order to diagnose the site of thrombi, radiolabeled streptokinase can be prepared. The radiolabeled compound can be used in imaging of thrombi in many cardiovascular diseases. Materials and Methods: Streptokinase was successively labeled with [67Ga]-gallium chloride using cyclic DTPA-dianhydride. The conjugation with DTPA was optimized for concentration, time and temperature foll...

In the first part of this two-part article, the characteristics, potential uses, radiochemical purity and method of evaluating the activity of Tc99m will be discussed. In the second part of the article, the dosimetry of this radionuclide will be presented for various routes of administration as well as for various chem ical configurations, such as the pertechnetate ion, the colloid and the prot...

We synthesized 18F-FDG by using an automated synthetic apparatus "FDG MicroLab" (GE Medical Systems) which produces 18F-FDG by a solid phase 18F-fluorination. Its quality and reproducibility were evaluated in order to assess feasibility of the apparatus for routine clinical production of 18F-FDG. For 5 consecutive 18F-FDG synthesis, target irradiation was carried out at 15 microA for 60 min. 18...

introduction: somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (prrt). in this study, 177lu-[dota-dphe1, tyr3]octreotide (177lu-dotatoc) as an agent for prrt was prepared and its biodistribution was studied in rats. methods:the best condition for the preparation of the 177lu-dotatoc radiolabeled complex was det...

introduction: radioimmunotherapy (rit) is a very promising new therapy for the treatment of recurrent b-cell non-hodgkin's lymphoma (nhl). iodine-131 is the most frequently used nuclide in clinical rit, but its usefulness has been limited by dehalogenation of monoclonal antibodies labeled via conventional methods. to circumvent this problem, we have synthesized a tri-peptide consisting of non-m...

The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the temperatures can be higher than those reported in the commercial illustrative leaflets of the kits. This is due, in particular, to the small size of the wo...

A synthesis of [“Qcopolamine capable of clinical delivery of this agent in high specific activity is described. The precursor [“Clformaldehyde was produced by catalytic oxidation of [“C]CH,OH over metallic silver and was used to N-“C-methylate norscopolamine using aqueous neutral potassium phosphite as the reducing agent. The labeling reaction was complete after 5min at 7580°C and the [“Clscopo...