PURPOSE Genetic alterations were previously identified in normal epithelia adjacent to invasive cancers. The aim of this study was to determine DNA methylation in histologically normal tissues from multiple geographic zones adjacent to primary breast tumors. EXPERIMENTAL DESIGN First, methylation status of a 4-kb region of RASSF1A promoter was interrogated using oligonucleotide-based microarr...

Aim: Mammography and ultrasonography are helpful diagnostic methods for the detection of asymptomatic lesions prior to reduction mammoplasty operations. Preoperative radiological evaluation does not give accurate results all time. Consequently, preoperative radilological and postoperative histopathologic evaluation were used together in order to diagnose the premalignant and silent cancer foci....

BACKGROUND In breast reconstruction, complementary surgery on the contralateral breast is sometimes necessary to obtain a satisfactory aesthetic result. This complementary mammoplasty for symmetry gives the surgeon the opportunity to verify the state of the mammary glandular tissue to rule out a possible occult tumour in the contralateral breast. Our objective was to determine the prevalence of...

Reduction mammoplasty is one of the most frequently performed procedures in plastic surgery for macromastia or gigantomastia. Recently it is also evolved for oncoplastic breast cancer surgery due to equivalent in terms of outcome for breast conserving surgery with radiotherapy versus mastectomy. Various techniques and modification has been made to achieve long lasting and aesthetically good res...

Background: Reduction mammoplasty is a technique used for treating women with breast hypertrophy, in addition to improving the appearance of these breasts. Hence, corrections under this include functional and aesthetic outcomes, while preserving vascularity sensibility Aim : To evaluate superomedial septal-based reduction patients hypertrophy on Nipple Areola Complex (NAC) vascularity, overall ...

PURPOSE We conducted a retrospective review following concerns involving a suspected increase in the requirement for surgical re-exploration for hematoma evacuation when ketorolac was administered perioperatively in patients undergoing reduction mammoplasty. METHODS Following ethics approval, a retrospective chart review was conducted of all patients who underwent reduction mammoplasty at our...

PURPOSE The aim of this study is to determine and to compare the oncological outcomes of bilateral reduction mammoplasty to standard breast-conserving surgery for breast cancer. METHODS One hundred sixty-two patients who received a quadrantectomy because of breast cancer (group 1) and 106 breast cancer patients with macromastia who underwent breast-conserving surgery via bilateral reduction m...

Quality of life (QoL) is an important outcome in plastic surgery. However, authors use different scales to address this subject, making it difficult to compare the outcomes. To address this discrepancy, the aim of this study was to perform a systematic review and a random effect meta-analysis. METHODS The search was made in two electronic databases (LILACS and PUBMED) using Mesh and non-Mesh ...