نتایج جستجو برای: resistant tumors
تعداد نتایج: 363377 فیلتر نتایج به سال:
Treatment of cancer patients with conventional therapies (chemotherapy, hormonal therapy, immunotherapy and radiation) respond initially well and experience prolonged tumor-free survival. However, in many patients tumor recurrences and relapses occur and such tumors exhibit the resistant phenotype i.e. cross-resistance to various cytotoxic and apoptotic agents. Therefore, new therapeutic strate...
طی دهه اخیر، پردازش تنک سیگنال ها به عنوان ابزاری قدرتمند و جایگزینی کارا برای تبدیل های کلاسیک، توجه زیادی را به خود جلب کرده است. استفاده از نمایش تنک سیگنال ها در مسائل طبقه بندی نیز نتایج موفقیت آمیزی به همراه داشته است. با این حال، کیفیت عملکرد این طبقه بندی کننده ها در شرایط سخت، از جمله در مواردی که داده های هر طبقه تنوع زیادی داشته و یا ابعاد داده ها در مقایسه با تعداد داده های آموزشی ز...
this study is a survey type of work on the plant tumors and their characteristics in genera1; special attention is given to those tumors which are caused by grobacterium tumefactions and also by plant hormones. the type of work and the methods are very much similar to the work of other investigators, but attempt was made to compare the results which are obtained upon the local varieties of a la...
Many tumors overexpress members of the inhibitor of apoptosis protein (IAP) family. IAPs contribute to tumor cell apoptosis resistance by the inhibition of caspases, and are degraded by the proteasome to allow further progression of apoptosis. Here we show that tumor cells can alter the specificity of cytosolic proteolysis in order to acquire apoptosis resistance, which promotes formation of ra...
PURPOSE Progression to the castration-resistant state is the incurable and lethal end stage of prostate cancer, and there is strong evidence that androgen receptor (AR) still plays a central role in this process. We hypothesize that knocking down AR will have a major effect on inhibiting growth of castration-resistant tumors. EXPERIMENTAL DESIGN Castration-resistant C4-2 human prostate cancer...
Castration-resistant progression of prostate cancer after androgen deprivation therapies remains the most critical challenge in the clinical management of prostate cancer. Resurgent androgen receptor (AR) activity is an established driver of castration-resistant progression, and upregulation of the full-length AR (AR-FL) and constitutively-active AR splice variants (AR-Vs) has been implicated t...
PURPOSE Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells. EXPERIMENTAL DESIGN Mice bearing two human RCC xenografts were treated with sorafenib until they acquired resistance. Resistant 786-O cells...
Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. Liposomes were prepared using different active loading techniques. The influence of diff...
pleuropulmonary blastoma (ppb) is a rare, malignant intrathoracic tumor that occurs mostly in children before 5 years old. it consists about 15% of all primary pediatric pulmonary tumors and shows various mesenchymal components. its presentations are nonspecific and common symptoms include fever, cough, chest pain, respiratory distress, and pulmonary infection. ppb should be considered in the d...
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