OBJECTIVE To determine residual acrylamide in medical polyacrylamide hydrogel by high performance liquid chromatography tandem mass spectroscopy (HPLC-MS). METHODS After (13)C3 labeled acrylamide was added, the sample was extracted with water and then cleaned up with Extrelut 20. The polyacrylamide hydrogel sample and 20 clinical cases were analyzed by HPLC-MS/MS and isotope dilution quantify...

Hydrogel materials consisting of water-swollen polymer networks exhibit a large number of specific properties highly attractive for a variety of optical biosensor applications. This properties profile embraces the aqueous swelling medium as the basis of biocompatibility, non-fouling behavior, and being not cell toxic, while providing high optical quality and transparency. The present review foc...

This paper describes a whole cell sensor using E. coli entrapped within photocrosslinked hydrogel beads. Hydrogel beads containing organophosphorus hydrolase (OPH)-expressed E. coli were prepared by adding a hydrogel precursor solution containing the E. coli to an oil phase using a precision syringe pump, forming droplets, and photopolymerizing them. The beads showed good monodispersity with an...

In this paper, inhomogeneous deformation of a temperature-sensitive hydrogel has been studied and analyzed under arbitrary geometric and boundary conditions. We present the governing equations and equilibrium conditions of an isothermal process based on the monophase gel field theory of hydrogel via a variational approach. We have adopted and implemented an explicit form of energy for temperatu...

Stimuli-sensitive hydrogels have received attention because of their potential applications in various fields. Stimuli-directed motion offers many practical applications, such as in drug delivery systems and actuators. Directed motion of asymmetric hydrogels has long been designed; however, few studies have investigated the motion control of symmetric hydrogels. We designed a pine cone scale-in...

Bovine and human serum albumin (BSA and HSA) are globular proteins that function as bloodstream carriers of hydrophobes such as fatty acids and drugs. We fabricated novel photonic crystal protein hydrogels by attaching 2D colloidal arrays onto pure BSA and HSA hydrogels. The wavelengths of the diffracted light sensitively report on the protein hydrogel surface area. The binding of charged speci...

Temperature has been extensively explored as a trigger to control the delivery of a payload from environment-sensitive polymers. The need for an external heat source only allows limited spatiotemporal control over the delivery process. We propose a new approach by using the dissipative properties of a hydrogel matrix as an internal heat source when the material is mechanically loaded. The syste...

Stimuli-responsive hydrogels exhibit structural changes based on changes in local temperature or pH and analytes and are highly valued in fields ranging from controlled drug release to tissue repair and also in microdevices. Hydrogels that respond to external stimuli, such as light or magnetic fields, offer additional advantageswith respect to on-demandand triggered response. With this in mind,...

Graphene oxide/poly(vinyl alcohol) (GO/PVA) composite hydrogel was prepared and utilized for selective drug release at physiological pH.

Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, a...