Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...

in the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. the rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a stoelting stereotaxic instrument. a stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. the third ventricular region was infus...

the aim of this research was to study the effect of eight weeks of selected aerobic exercises on depression and serum serotonin concentration in depressed female university students aged between 18 and 25 in aligudarz city. for this purpose, using beck depression questionnaire, 20 female students with moderate depression were selected in two groups (experimental n = 10 and control n=10). to eva...

Introduction: Previous studies have shown that ghrelin inhibits the activity of Hypothalamus –Pituitary – Thyroid (H–P-T) axis. It is also proved that ghrelin increases appetite via Agouti Related Protein and neuropeptide Y pathway, decreases T3 & T4 secretion and inhibits serotonin release from hypothalamic synaptosomes. Serotonin may interact with ghrelin in control of thyroid hormones secr...

intramascular (im) administration of apomorphine (a mixed d1/d2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. in this study the effect of lithium (li+, 240 mg/kg, im) and ami-193 (a new 5-ht2 antagonist, 0.003 mg/pigeon) on apomorphine-induced peking (aip) were investigated. this study showed that li+ and ami-193 did not...

the effect of endogenous serotonin on long-term potentiation (ltp) in region cai was studied by blocking 5-ht2 receptors with ketanserin in rat hippocampal slices. such a block significantly en-hanced long-term potentiation of the cai population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. this implies that serotonin acts on 5-ht2 receptors in cai...

Sleep disturbance, known as insomnia, is a common symptom of many mental illnesses. Insomnia is one of the most prevalent sleep disorders characterized by sleep difficulty that affects our life and work safety. Several lines of evidence support the primary insomnia as a risk factor/predictor for depression and anxiety disturbances. Anxiety disorders and insomnia are common, debilitating and hig...

Abstract Plasticity is a fundamental property of the neural system controlling breathing. One key example respiratory motor plasticity phrenic long-term facilitation (pLTF), persistent increase in nerve activity elicited by acute intermittent hypoxia (AIH). pLTF can arise from distinct cell signaling cascades initiated serotonin versus adenosine receptor activation, respectively; these interact...