Background: Although rare, serum sickness-like reactions have been documented to occur following the administration of many antibiotics including the second generation cephalosporin cefaclor. Cefazolin, which belongs to the first generation of the same drug class, is a commonly prescribed antibiotic which is considered to be generally safe and well tolerated. There have been no prior reports li...

A simultaneous pancreas-kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment with high-dose glucocorticoids. rATG is increasingly favoured over equine ATG in solid-organ transpl...

Case Report A bus-fitter, aged 36 years, was given tetanus antitoxin for a cut finger; a similar injection had been received twelve years previously without reaction. Seven days later a general urticarial rash appeared, and two hours later he felt faint and fell to his knees. He went to bed and slept for six hours, waking with pruritus and mild precordial pain; after a subcutaneous injection of...

BACKGROUND In Alzheimer disease (AD), systemic inflammation is known to give rise to a delirium. However, systemic inflammation also gives rise to other centrally mediated symptoms in the absence of a delirium, a concept known as sickness behavior. Systemic inflammation is characterized by the systemic production of the proinflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-6 ...