OBJECTIVE To evaluate the effects of ezetimibe/simvastatin (EZE/SIMV) and rosuvastatin (ROSUV) on oxidative stress (OS) markers in patients with diabetic polyneuropathy (DPN). METHODS We performed a randomized, double-blind, placebo-controlled phase III clinical trial in adult patients with Type 2 Diabetes Mellitus (T2DM) and DPN, as evaluated by composite scores and nerve conduction studies ...

BACKGROUND Various modes of mechanical ventilation have different effects on respiratory variables. Lack of patients' neuro-ventilatory coordination and increasing the work of breathing are major disadvantages in mechanically ventilated patients. OBJECTIVES This study is conducted to compare the respiratory parameters differences in Adaptive support ventilation (ASV) and synchronized intermit...

BACKGROUND Patients undergone mechanical ventilation need rapid and reliable evaluation of their respiratory status. Monitoring of End-tidal carbon dioxide (ETCO2) as a surrogate, noninvasive measurement of arterial carbon dioxide (PaCO2) is one of the methods used for this purpose in intubated patients. OBJECTIVES The aim of the present trial was to study the relationship between end-tidal C...

results sixty patients were involved in this study. in asv mode, values including peak airway pressure (p-peak), end-tidal carbon dioxide (etco2), tidal volume and respiratory dead space were significantly lower than simv mode. although the mean value for dynamic compliance had no significant difference in the two types of ventilation, it was better in asv mode. methods in a crossover study, pa...

results the level of gsh significantly decreased. in contrast, the plasma level of mda significantly increased in a dose dependent manner in crvi-treated rats, when compared to control animals. simv had no effect on the biochemical parameters when compared to control rats, but significantly increased gsh concentration and decreased mda level in crvi-treated rats. materials and methods sixty-fou...

Dyslipidemia is a metabolic condition linked to increased morbidity. This study aimed evaluate the effect of two new nutraceuticals derived from annatto (Bixa orellana), açaí (Euterpe oleracea), and soybean germ or red clover isoflavones (Trifolium pratense) against high-fat-induced dyslipidemia in female Wistar rats. The formulations were assessed through GC-MS HPLC-UV/Vis. Next, rats received...

conclusions the observations suggest that simv may have a protective effect against cr(vi)-induced oxidative stress in the rat lung. background chromium is a naturally occurring heavy metal found in the environment. objectives the aim of the present study was to determine the effect of simvastatin (simv) on sodium dichromate [cr(vi)]-induced oxidative stress in the rat lung. materials and metho...